Evidence map›Paper›PMID 33385519›Full record

ArticleBiochimica et biophysica acta. Molecular basis of disease2021

Incomplete mitophagy in the mevalonate kinase-deficient Saccharomyces cerevisiae and its relation to the MKD-related autoinflammatory disease in humans.

Manuella Maria Silva Santos, Damián Gatica, Jaqueline de Azêvedo Silva, Sergio Crovella, Daniel J Klionsky, Marcos Antonio De Morais

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Molecular basis of disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Manuella Maria Silva SantosDepartment of Genetics, Federal University of Pernambuco, Avenida Moraes Rego, No. 1235, Recife, PE 50760-901, Brazil.
Damián GaticaLife Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Jaqueline de Azêvedo SilvaDepartment of Genetics, Federal University of Pernambuco, Avenida Moraes Rego, No. 1235, Recife, PE 50760-901, Brazil; Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco, Avenida Moraes Rego, No. 1235, Recife, PE 50760-901, Brazil.
Sergio CrovellaDepartment of Genetics, Federal University of Pernambuco, Avenida Moraes Rego, No. 1235, Recife, PE 50760-901, Brazil; Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco, Avenida Moraes Rego, No. 1235, Recife, PE 50760-901, Brazil.
Daniel J KlionskyLife Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Marcos Antonio De MoraisDepartment of Genetics, Federal University of Pernambuco, Avenida Moraes Rego, No. 1235, Recife, PE 50760-901, Brazil. Electronic address: marcos.moraisjr@ufpe.br.
Universidade Federal de Pernambuco · BRUniversity of Michigan · US

Funding

The mechanism and regulation of autophagyR35GM131919 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DANIEL J. KLIONSKY · 2019 to 2026
$6.4M
NIGMS NIH HHS R35 GM131919
6 · The paper itself

Abstract

Mevalonate kinase deficiency (MKD) is an autosomal recessive disorder in humans that causes systemic autoinflammatory problems to children. Previously, we used a yeast model to show that MKD results in mitochondrial malfunctioning that may finally induce mitophagy. Here, we proved that MKD indeed induced general autophagy as well as mitophagy in yeast, but these mechanisms did not go to completion. Therefore, the limitation of mevalonate kinase activity produces dysfunctional mitochondria that might not be recycled, causing metabolic dysfunctions in the cells. Understanding this mechanism may provide a piece in solving the nonspecific autoinflammatory response puzzle observed in MKD patients.

Indexed as

MitophagyGene DeletionHumansMevalonate Kinase DeficiencyPhosphotransferases (Alcohol Group Acceptor)Saccharomyces cerevisiaeSaccharomyces cerevisiae Proteinsmevalonate kinasePhosphotransferases (Alcohol Group Acceptor)Saccharomyces cerevisiae ProteinsAutoinflammatory disordersAutophagyErg12Mevalonate kinase deficiencyMitochondrial disorderMitophagy

Identifiers

PMID33385519
PMCPMC8011287
OpenAlexW3116085397

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.