ArticleNeurobiology of disease2021
Brain pathology caused in the neonatal macaque by short and prolonged exposures to anticonvulsant drugs.
Open access · goldAbstract read
In one paragraph
Article in Neurobiology of disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 21 citations in OpenAlex.
- GPCR-Driven Muscarinic M1 and Histamine H1 Receptor Signaling Converging on the PI3K/Akt/mTOR Pathway: Functional Integration in Neuroinflammation and Myelin Repair in Multiple Sclerosis.Molecular neurobiology · 2026Review
- Tiny doses, big impact: Optimizing sedation weaning to reduce opioid use in a Level IV NICU.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Febrile Seizures in an App-Based Children's Fever Registry: Mixed Methods Study.JMIR pediatrics and parenting · 2026Article
- Prominent astrocytic GLAST pathology occurs in newborn human and piglet hypoxic-ischemic encephalopathy: modeling relationships among laminar neuropathology, seizures, and therapeutic hypothermia.Frontiers in cellular neuroscience · 2026Article
- Case Report: Early non-convulsive status epilepticus in a preterm infant with recurrent refractoryFrontiers in pediatrics · 2026Article
- Pharmacokinetics and Pharmacodynamics of Levetiracetam in Neonatal Seizures: What We Still Need to Know.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2025Article
- The gain-of-function UBE3AScientific reports · 2025Article
- Padsevonil suppresses seizures without inducing cell death in neonatal rats.Pharmacological reports : PR · 2024Article
- Lacosamide and Levetiracetam Are Not Toxic to the Developing Mouse Brain.Annals of neurology · 2024Article
- Cenobamate suppresses seizures without inducing cell death in neonatal rats.Epilepsy & behavior : E&B · 2024Article
- Anti-seizure medication-induced developmental cell death in neonatal rats is unaltered by history of hypoxia.Epilepsy research · 2024Article
- Questions and Controversies in Neonatal Seizures.Children (Basel, Switzerland) · 2023Review
- Article
- Behavioral and Cognitive Outcomes of Rhesus Macaques Following Neonatal Exposure to Antiseizure Medications.Annals of neurology · 2023Article
- Early Discontinuation of Phenobarbital After Acute Symptomatic Neonatal Seizures in the Term Newborn.Neurology. Clinical practice · 2023Article
- Mild hypothermia fails to protect infant macaques from brain injury caused by prolonged exposure to Antiseizure drugs.Neurobiology of disease · 2022Article
- Novel Therapeutics for Neonatal Seizures.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Treating Seizures after Hypoxic-Ischemic Encephalopathy-Current Controversies and Future Directions.International journal of molecular sciences · 2021Review
- Effects of Midazolam on the Development of Adult Leydig Cells From Stem CellsFrontiers in endocrinology · 2021Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Kevin K NoguchiDepartment of Psychiatry, Washington University, School of Medicine, St Louis, USA.
Nicole A FuhlerDepartment of Psychiatry, Washington University, School of Medicine, St Louis, USA.
Sophie H WangDepartment of Psychiatry, Washington University, School of Medicine, St Louis, USA.
Saverio CapuanoWisconsin National Primate Research Center, Madison, WI, USA.
Kevin R BrunnerWisconsin National Primate Research Center, Madison, WI, USA.
Shreya LarsonWisconsin National Primate Research Center, Madison, WI, USA.
Kristin CrosnoWisconsin National Primate Research Center, Madison, WI, USA.
Heather A SimmonsWisconsin National Primate Research Center, Madison, WI, USA.
Andres F MejiaWisconsin National Primate Research Center, Madison, WI, USA.
Lauren D MartinDivision of Comparative Medicine, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA.
Gregory A DissenDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA.
Ansgar BrambrinkDepartment of Anesthesiology, Columbia University, New York Presbyterian Hospital, Irving Medical Center, New York, NY, USA.
Chrysanthy IkonomidouDepartment of Neurology, University of Wisconsin, School of Medicine, Madison, WI, USA. Electronic address: Ikonomidou@neurology.wisc.edu.
Washington University in St. Louis · USNew York Hospital Queens · USOregon Health & Science University · USOregon National Primate Research Center · USUniversity of Wisconsin–Madison · US
Funding
Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9MWNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7MPhase 2 Enhancement of Outdoor Group Housing for U42 SPF 9 Rhesus MacaquesU42OD023038 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Samuel Peterson · 2016 to 2026
$21.9MWUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JEFFREY D MILBRANDT · 2020 to 2026
$15.5MWashington University Intellectual and Developmental Disabilities Research Center-Administrative Down Syndrome SupplementU54HD087011 · NICHD · WASHINGTON UNIVERSITY · PI MOLEY, KELLE H · 2015 to 2019
$7.1MMass Spectrometric Studies of Neuropeptides in FeedingR01DK071801 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI LINGJUN LI · 2006 to 2026
$6.7MViral Testing CoreU42OD010426 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Samuel Peterson · 2013 to 2026
$6.0MWashington University Intellectual and Developmental Disabilities Research CenterP30HD062171 · NICHD · WASHINGTON UNIVERSITY · PI INDER, TERRIE E · 2010 to 2014
$4.3MANESTHESIA TOXICITY IN NEONATAL PRIMATE BRAINR01HD052664 · NICHD · WASHINGTON UNIVERSITY · PI NOGUCHI, KEVIN K · 2007 to 2016
$4.0MHYPOTHERMIA TO PREVENT NEUROTOXIC SIDE EFFECTS OF PEDIATRIC DRUGSR01HD083001 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI IKONOMIDOU, HRISSANTHI · 2016 to 2019
$2.1MIn Situ Protein Characterization and Visualization in the Brains of Mouse Models for AutismR56MH110215 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI IKONOMIDOU, HRISSANTHI, LI, LINGJUN · 2017 to 2018
$752kNICHD NIH HHS P30 HD062171NICHD NIH HHS P50 HD103525NICHD NIH HHS R01 HD052664NICHD NIH HHS R01 HD083001NICHD NIH HHS U54 HD087011NIDDK NIH HHS R01 DK071801NIH HHS P51 OD011092NIH HHS P51 OD011106NIH HHS U42 OD010426NIH HHS U42 OD023038NIMH NIH HHS R56 MH110215
Abstract
Barbiturates and benzodiazepines are potent GABA
Indexed as
AnimalsAnimals, NewbornAnticonvulsantsBrainDrug Administration ScheduleMacaca mulattaAnticonvulsantsAnticonvulsantAntiepilepticApoptosisBarbiturateBenzodiazepineBrain injuryDevelopmentSedative
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.