ArticleJournal of the American Academy of Child and Adolescent Psychiatry2021
Amygdala Functional Connectivity and Negative Reactive Temperament at Age 4 Months.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- From Infant Temperament to Anxiety: Infant Neural Responsivity to Unexpected Stimuli Shapes Outcomes.Biological psychiatry · 2026Article
- Neural correlates of child temperament: The role of brain network connectivity in psychopathology risk.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Neonatal amygdala microstructure and structural connectivity are associated with autistic traits at 2 years of age.Developmental cognitive neuroscience · 2026Article
- Bridging the gap: Translating fetal, infant, and toddler neuroimaging insights into clinical practice.Developmental cognitive neuroscience · 2026Review
- Longitudinal Changes in Infant Attention-Related Brain Networks and Fearful Temperament.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Neonatal Brain Volumes and Early Parenting Behavior as Mediators in Associations Between Prenatal Social Disadvantage and Socioemotional Problems in Toddlers.Biological psychiatry · 2026Article
- The promise of infant MRI in psychiatry: toward a framework for neural network measures in early emotional and behavioral risk identification and new intervention targets.Molecular psychiatry · 2026Review
- Early-life neural correlates of behavioral inhibition and anxiety risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Sex-Specific Effects of Early-Life Unpredictability on Hippocampal and Amygdala Responses to Novelty in Adolescents.Biological psychiatry global open science · 2025Article
- Human amygdala nuclei show distinct developmental trajectories from adolescence to adulthood in functional integration with prefrontal circuitry.Cell reports · 2025Article
- Temperament development in infancy: What we have learned about the origins of individual differences in the past 25 years.Infant behavior & development · 2025Review
- Infants' resting-state functional connectivity and event-related potentials: A multimodal approach to investigating the neural basis of infant novelty detection.Developmental psychology · 2025Article
- Neurodevelopmental Pathways from Temperamental Fear to Anxiety.Current topics in behavioral neurosciences · 2025Review
- Neonatal neural responses to novelty related to behavioral inhibition at 1 year.Developmental psychology · 2024Article
- Neural Correlates of Novelty-Evoked Distress in 4-Month-Old Infants: A Synthetic Cohort Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Longitudinal associations between language network characteristics in the infant brain and school-age reading abilities are mediated by early-developing phonological skills.Developmental cognitive neuroscience · 2024Article
- Longitudinal associations between language network characteristics in the infant brain and school-age reading abilities are mediated by early-developing phonological skills.bioRxiv : the preprint server for biology · 2024Article
- Associations between infant amygdala functional connectivity and social engagement following a stressor: A preliminary investigation.Developmental science · 2024Article
- Concurrent and prospective associations between infant frontoparietal and default mode network connectivity and negative affectivity.Biological psychology · 2023Article
- Annual Research Review: Developmental pathways linking early behavioral inhibition to later anxiety.Journal of child psychology and psychiatry, and allied disciplines · 2023Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveInfant amygdala connectivity correlates with maternal reports of infant temperament characterized by novelty-evoked distress and avoidance. However, no studies have examined how human infant amygdala connectivity relates to direct observations of novelty-evoked distress. This study examined the link between amygdala connectivity and infant novelty-evoked distress using direct observation of temperament.
methodNovelty-evoked distress was assessed at 4 months of age (N = 90) using a standardized reactivity assessment and parent report. Within 3 weeks of assessment, resting-state functional magnetic resonance imaging was collected in a subset of infants (n = 34). Using a whole-brain voxelwise approach, amygdala connectivity associated with positive and negative affect during the reactivity assessment was examined. Regions where the association of amygdala connectivity with negative affect was higher than with positive affect were then examined. Associations between amygdala connectivity and parent report of temperament were also examined.
resultsGreater amygdala-cingulate and amygdala-superior frontal gyrus connectivity was associated with lower positive affect during the reactivity assessment. Further, the association between amygdala-cingulate connectivity was greater for negative affect compared with positive affect. There were no significant associations between latency to approach novelty (as measured by parent report) and amygdala connectivity. Validation analyses conducted using a large independent longitudinal sample (N = 323) demonstrated that negative reactivity was associated with increased child-reported anxiety symptoms in adolescence.
conclusionThese results provide novel insight into the developmental pathophysiology of novelty-evoked distress. This is consistent with research linking an altered cognitive control mechanism to temperamental risk for anxiety.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.