Evidence map›Paper›PMID 33385503›Full record

ReviewCellular signalling2021

Biased agonism at β-adrenergic receptors.

Michael Ippolito, Jeffrey L Benovic

Open access · greenAbstract readReview
In one paragraph

Review in Cellular signalling, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Unique/Rapid Feedback Mechanisms of PGDBioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Implication of Central βArchiv der Pharmazie · 2025
    Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Role of G protein-coupled receptor kinases (GRKs) in βPharmacology research & perspectives · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Michael IppolitoDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, United States of America.
Jeffrey L BenovicDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, United States of America. Electronic address: jeffrey.benovic@jefferson.edu.
Thomas Jefferson University · US

Funding

Project 4 - OGR1- and TSPO- dependent mechanisms mediated by benzodiazepines affecting ASM contractionP01HL114471 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BENOVIC, JEFFREY L · 2013 to 2023
$23.9M
Regulation of G protein-coupled receptor signaling and traffickingR35GM122541 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI BENOVIC, JEFFREY L · 2017 to 2021
$2.5M
Characterization of beta-arrestin-biased beta 2-adrenergic receptor signaling in cardiovascular functionR01HL136219 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI BENOVIC, JEFFREY L, TILLEY, DOUGLAS · 2017 to 2020
$2.5M
Training Program in Cellular, Biochemical, and Molecular SciencesT32GM100836 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI BENOVIC, JEFFREY L · 2012 to 2016
$809k
Characterization and Development of Gs-biased ligands of Beta2-Adrenergic ReceptorF31HL139104 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI IPPOLITO, MICHAEL · 2018 to 2019
$90k
NHLBI NIH HHS F31 HL139104NHLBI NIH HHS P01 HL114471NHLBI NIH HHS R01 HL136219NIGMS NIH HHS R35 GM122541NIGMS NIH HHS T32 GM100836
6 · The paper itself

Abstract

The β-adrenergic receptors (βARs) include three subtypes, β

Indexed as

Adrenergic beta-Agonistsbeta-Arrestin 1HumansHypertensionLigandsProtein IsoformsReceptors, Adrenergic, betaReceptors, G-Protein-CoupledSignal TransductionAdrenergic beta-Agonistsbeta-Arrestin 1LigandsProtein IsoformsReceptors, Adrenergic, betaReceptors, G-Protein-CoupledArrestinG protein-coupled receptorGRKPhosphorylationSignaling

Identifiers

PMID33385503
PMCPMC7878421
OpenAlexW3113860860

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.