Evidence map›Paper›PMID 33385298›Full record

ArticleInfection2021

Macrophage migration inhibitory factor - 794 CATT

Felipe Dominguez Machado, Mirela Gehlen, Vitória Schmidt Caron, Gabriel Tassi Mousquer, Graziele Lima Bello, Camila Anton, Rafaela Manzoni Bernardi, Alana Ambos Freitas, Gisela Unis, Elis Regina Dalla Costa and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Infection, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Felipe Dominguez MachadoPrograma de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Mirela GehlenPrograma de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Vitória Schmidt CaronCentro de Desenvolvimento Científico e Tecnológico, Secretaria Estadual da Saúde do Rio Grande do Sul (CDCT/SES), Porto Alegre, RS, Brazil.
Gabriel Tassi MousquerPrograma de Pós-Graduação em Biociências da Universidade Federal de Ciências da Saúde de Porto Alegre (UFSCPA), Porto Alegre, RS, Brazil.
Graziele Lima BelloPrograma de Pós-Graduação em Biologia Molecular e Celular Aplicada a Saúde (Biosaúde), Universidade Luterana do Brasil (ULBRA), Canoas, RS, Brazil.
Camila AntonPrograma de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Rafaela Manzoni BernardiPrograma de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Alana Ambos FreitasFaculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), 2350 Ramiro Barcelos Street, Room 2050, Porto Alegre, RS, 90035-903, Brazil.
Gisela UnisHospital Sanatório Partenon, Porto Alegre, RS, Brazil.
Elis Regina Dalla CostaCentro de Desenvolvimento Científico e Tecnológico, Secretaria Estadual da Saúde do Rio Grande do Sul (CDCT/SES), Porto Alegre, RS, Brazil.
Maria Lucia Rosa RossettiPrograma de Pós-Graduação em Biologia Molecular e Celular Aplicada a Saúde (Biosaúde), Universidade Luterana do Brasil (ULBRA), Canoas, RS, Brazil.
Denise Rossato SilvaPrograma de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. denise.rossato@terra.com.br.ORCID http://orcid.org/0000-0003-0230-2734

Funding

FIPE-HCPA 160599
6 · The paper itself

Abstract

purposeThe establishment of candidate genetic determinants associated with tuberculosis (TB) is a challenge, considering the divergent frequencies among populations. The objective of this study was to evaluate the association between MIF - 794 CATT

methodsCase-control study. Patients > 18 years, with pulmonary TB were included. The control group consisted of blood donors and household contacts, not relatives, healthy and > 18 years. MIF - 794 CATT

results126 patients and 119 controls were included. The genotype 5/5 was more frequent among cases (15.1%) than in controls (5.9%) (p = 0.019). Cases had more frequently the allele 5 (29.4%) as compared with controls (19.3%) (p = 0.010). Prevalence of 7/X + 8/X genotypes was not different between cases and controls (p = 0.821). There was no difference between patients with alleles 7 and 8 and those with alleles 5 and 6 (p = 0.608).

conclusionsThe genotype 5/5 and the allele 5 of MIF - 794 CATT

Indexed as

Genetic Predisposition to DiseaseMacrophage Migration-Inhibitory FactorsTuberculosisCase-Control StudiesGene FrequencyGenotypeHumansIntramolecular OxidoreductasesMicrosatellite RepeatsPolymorphism, Single NucleotideIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMIF protein, humanMacrophage migration inhibitory factorPolymorphismSingle nucleotide polymorphismSusceptibilityTuberculosis

Identifiers

PMID33385298

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.