Evidence map›Paper›PMID 33385279›Full record

Trial reportAIDS and behavior2021

TransPrEP: Results from the Pilot Study of a Social Network-Based Intervention to Support PrEP Adherence Among Transgender Women in Lima, Peru.

Jesse Clark, Sari Reisner, Amaya Perez-Brumer, Leyla Huerta, Hugo Sanchez, Kathleen Moriarty, Maria Mamani Luque, Hideaki Okochi, Ximena Salazar, Matthew Mimiaga and 4 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in AIDS and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. A Scoping Review of Biobehavioural Interventions to Improve PrEP Continuum of Care in Latin America.Acta colombiana de psicologia : revista de la Facultad de Psicologia, Universidad Catolica de Colombia · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jesse ClarkUCLA Geffen School of Medicine, Los Angeles, CA, USA. jlclark@mednet.ucla.edu.ORCID http://orcid.org/0000-0001-5862-6530
Sari ReisnerThe Fenway Institute, Boston, MA, USA.
Amaya Perez-BrumerDalla Lana School of Public Health, University of Toronto, Toronto, Canada.
Leyla HuertaFeminas, Lima, Peru.
Hugo SanchezEpicentro, Lima, Peru.
Kathleen MoriartyUCLA Geffen School of Medicine, Los Angeles, CA, USA.
Maria Mamani LuqueAsociacion Civil Impacta Salud y Educacion, Lima, Peru.
Hideaki OkochiUniversity of California, San Francisco, CA, USA.
Ximena SalazarInstituto de Estudios de Salud Sexual y Derechos Humanos, Lima, Peru.
Matthew MimiagaThe Fenway Institute, Boston, MA, USA.
Jorge SanchezCentro de Investigaciones Tecnológicas Biomédicas y Medioambientales, Universidad Nacional San Marcos, Lima, Peru.
Monica GandhiUniversity of California, San Francisco, CA, USA.
Kenneth H MayerThe Fenway Institute, Boston, MA, USA.
Javier R LamaAsociacion Civil Impacta Salud y Educacion, Lima, Peru.

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ARTHUR Y KIM · 2004 to 2026
$94.4M
Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Sung-Jae Lee · 1997 to 2026
$53.5M
Study of Hearing and Balance in Middle Aged and Aging Men and Women in the MACS-WIHS Combined Cohort StudyU01HL146333 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Roger Detels, Matthew James Mimiaga · 2019 to 2026
$32.2M
Plugging Hair ARV Levels as Adherence Biomarkers into HIV Prevention TrialsR01AI098472 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GANDHI, MONICA · 2012 to 2021
$5.6M
South American Program in HIV Prevention Research (SAPHIR)R25MH087222 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JESSE LAWTON CLARK, Karin Nielsen · 2011 to 2026
$3.9M
The Brown Initiative in HIV and AIDS Clinical Research for Minority CommunitiesR25MH083620 · NIMH · MIRIAM HOSPITAL · PI NUNN, AMY STEWART · 2008 to 2025
$3.7M
TransPrEP: Social Network-Based PrEP Adherence for Transgender Women in PeruR34MH104072 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CLARK, JESSE LAWTON, MIMIAGA, MATTHEW JAMES · 2014 to 2016
$672k
NHLBI NIH HHS U01 HL146333NIAID NIH HHS P30 AI027763NIAID NIH HHS P30 AI060354NIAID NIH HHS R01 AI098472NIMH NIH HHS P30 MH058107NIMH NIH HHS R25 MH083620NIMH NIH HHS R25 MH087222NIMH NIH HHS R34 MH104072
6 · The paper itself

Abstract

We conducted a pilot randomized controlled trial of a social network-based intervention to promote PrEP adherence among transgender women (TW) in Lima, Peru. We enrolled 89 TW from six social networks and cluster-randomized them 1:1 to standard of care (n = 44) or the TransPrEP intervention (n = 45). Core workshops discussed strategies to support PrEP adherence and defined group adherence objectives. Maintenance workshops discussed participants' experiences taking PrEP and collective adherence goals. At 3-month follow-up, we evaluated 40 participants and obtained 29 hair samples for tenofovir level measurements. Though no significant differences were observed, 36.4% (4/11) of participants of TransPrEP participants and 10.0% (1/10) of control participants had tenofovir levels > 0.023 ng/mg, consistent with ≥ 4 doses per week. 81.8% (9/11) of intervention and 40.0% (4/10) of control participants had any detectable tenofovir in their hair. Pilot assessment of our network-based intervention suggested a trend towards improved PrEP adherence, measured objectively, for TW in Peru.

Indexed as

Anti-HIV AgentsHIV InfectionsPre-Exposure ProphylaxisTransgender PersonsFemaleHomosexuality, MaleHumansMaleMedication AdherencePeruPilot ProjectsSocial NetworkingAnti-HIV AgentsAdherenceLatin americaPre-exposure prophylaxis (PrEP)Transgender women

Identifiers

PMID33385279
PMCPMC8084919

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.