Observational studyJournal of clinical monitoring and computing2022
Focus on renal blood flow in mechanically ventilated patients with SARS-CoV-2: a prospective pilot study.
Observational study in Journal of clinical monitoring and computing, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06638255 (Effects of High Positive End-expiratory Pressure Over Abdominal Venous Congestion, Visceral Edema, and Organ Dysfunction, in Mechanically Ventilated ARDS Patients), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of High Positive End-expiratory Pressure Over Abdominal Venous Congestion, Visceral Edema, and Organ Dysfunction, in Mechanically Ventilated ARDS Patients: a Randomized Cross-over Study
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Respiratory system mechanics, gas exchange, and outcomes in mechanically ventilated patients with COVID-19-related acute respiratory distress syndrome: a systematic review and meta-analysis.The Lancet. Respiratory medicine · 2022Pooled it
- Venous congestion from a vascular waterfall perspective: reframing congestion as a dynamic Starling resistor phenomenon.Intensive care medicine experimental · 2025Review
- PEEP-AKI-COVID ICU: Effect of positive end-expiratory pressure on acute kidney injury development in patients with COVID-19-associated acute respiratory distress syndrome: an ancillary analysis of the COVID-ICU study.Journal of intensive care · 2025Article
- SARS-CoV-2 Infection Is Associated with an Accelerated eGFR Decline in Kidney Transplant Recipients up to Four Years Post Infection.Diagnostics (Basel, Switzerland) · 2025Article
- Ventilation-induced acute kidney injury in acute respiratory failure: Do PEEP levels matter?Critical care (London, England) · 2025Review
- Plasma expansion and renal perfusion in critical COVID-19 with AKI: A prospective case control study.Acta anaesthesiologica Scandinavica · 2025Article
- Exploring the Utility of Renal Resistive Index in Critical Care: Insights into ARDS and Cardiac Failure.Biomedicines · 2025Review
- Article
- Impact of positive end-expiratory pressure on renal resistive index in mechanical ventilated patients.Journal of clinical monitoring and computing · 2024Article
- Perfusion deficits may underlie lung and kidney injury in severe COVID-19 disease: insights from a multicenter international cohort study.Journal of anesthesia, analgesia and critical care · 2024Review
- Temporal Relationship and Clinical Outcomes of Acute Kidney Injury Following Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis.Critical care explorations · 2024Review
- Incidence, risk factors and outcome of acute kidney injury in critically ill COVID-19 patients in Tyrol, Austria: a prospective multicenter registry study.Journal of nephrology · 2023Article
- The role of kidney injury biomarkers in COVID-19.Renal failure · 2022Review
- Urinary tubular biomarkers as predictors of death in critically ill patients with COVID-19.Biomarkers in medicine · 2022Article
- [Acute kidney injury and COVID-19: lung-kidney crosstalk during severe inflammation].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2022Review
- Kidney Injury in COVID-19: Epidemiology, Molecular Mechanisms and Potential Therapeutic Targets.International journal of molecular sciences · 2022Review
- Acute kidney injury (AKI) in patients with Covid-19 infection is associated with ventilatory management with elevated positive end-expiratory pressure (PEEP).Journal of nephrology · 2022Observational
- Pathophysiology of COVID-19-associated acute kidney injury.Nature reviews. Nephrology · 2021Review
- Management of Intraoperative Mechanical Ventilation to Prevent Postoperative Complications after General Anesthesia: A Narrative Review.Journal of clinical medicine · 2021Review
- Relationship between Driving Pressure and Mortality in Ventilated Patients with Heart Failure: A Cohort Study.Canadian respiratory journal · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanically ventilated patients with ARDS due to the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) seem particularly susceptible to AKI. Our hypothesis was that the renal blood flow could be more compromised in SARS-CoV-2 patients than in patients with "classical" ARDS. We compared the renal resistivity index (RRI) and the renal venous flow (RVF) in ARDS patients with SARS-CoV-2 and in ARDS patients due to other etiologies. Prospective, observational pilot study performed on 30 mechanically ventilated patients (15 with SARS-COV-2 ARDS and 15 with ARDS). Mechanical ventilation settings included constant-flow controlled ventilation, a tidal volume of 6 ml/kg of ideal body weight and the PEEP level titrated to the lowest driving pressure. Ultrasound Doppler measurements of RRI and RVF pattern were performed in each patient. Patients with SARS-COV-2 ARDS had higher RRI than patients with ARDS (0.71[0.67-0.78] vs 0.64[0.60-0.74], p = 0.04). RVF was not-continuous in 9/15 patients (71%) in the SARS-COV-2 ARDS group and in and 5/15 (33%) in the ARDS group (p = 0.27). A linear correlation was found between PEEP and RRI in patients with SARS-COV-2 ARDS (r
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.