Evidence map›Paper›PMID 33385213›Full record

ArticleAmerican journal of respiratory cell and molecular biology2021

TBX4 Transcription Factor Is a Positive Feedback Regulator of Itself and Phospho-SMAD1/5.

Ying Cai, Ling Yan, Matthew J Kielt, Joy D Cogan, Lora K Hedges, Bethany Nunley, James West, Eric D Austin, Rizwan Hamid

Open access · greenAbstract readLetter
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Tumors and their microenvironments: Learning from pediatric brain pathologies.Biochimica et biophysica acta. Reviews on cancer · 2025
    Review
  5. Article
  6. Defining the clinical validity of genes reported to cause pulmonary arterial hypertension.Genetics in medicine : official journal of the American College of Medical Genetics · 2023
    Article
  7. Review
  8. Article
  9. Molecular genetics of pulmonary hypertension in children.Current opinion in genetics & development · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ying CaiVanderbilt University Medical Center Nashville, Tennessee and.
Ling YanVanderbilt University Medical Center Nashville, Tennessee and.
Matthew J KieltNationwide Children's Hospital Columbus, Ohio.
Joy D CoganVanderbilt University Medical Center Nashville, Tennessee and.
Lora K HedgesVanderbilt University Medical Center Nashville, Tennessee and.
Bethany NunleyVanderbilt University Medical Center Nashville, Tennessee and.
James WestVanderbilt University Medical Center Nashville, Tennessee and.
Eric D AustinVanderbilt University Medical Center Nashville, Tennessee and.ORCID 0000-0002-1709-9022
Rizwan HamidVanderbilt University Medical Center Nashville, Tennessee and.
Vanderbilt University Medical Center · USNationwide Children's Hospital · US

Funding

Sex Hormones in Pulmonary Arterial HypertensionP01HL108800 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI NEWMAN, JOHN HUGHES · 2012 to 2021
$22.0M
Interventions Against the Molecular Etiology of BMPR2-induced PAHR01HL095797 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WEST, JAMES D · 2010 to 2022
$6.7M
Estrogen signaling and energy metabolism in pulmonary arterial hypertensionR01HL134802 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI AUSTIN, ERIC DOUGLAS · 2018 to 2022
$3.7M
Role of BMPR2 expression in HPAH; implications for novel therapeutic approachesR01HL102020 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HAMID, RIZWAN · 2011 to 2015
$2.3M
NHLBI NIH HHS P01 HL108800NHLBI NIH HHS R01 HL095797NHLBI NIH HHS R01 HL102020NHLBI NIH HHS R01 HL134802
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCell LineFeedbackGene Expression RegulationHumansSignal TransductionSmad1 ProteinSmad5 ProteinT-Box Domain ProteinsTranscription FactorsSmad1 ProteinSmad5 ProteinT-Box Domain ProteinsTranscription Factors

Identifiers

PMID33385213
PMCPMC7780990
OpenAlexW3114387741

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.