Evidence map›Paper›PMID 33385180›Full record

ArticleThrombosis and haemostasis2022

Gain-of-Function Variant p.Pro2555Arg of von Willebrand Factor Increases Aggregate Size through Altering Stem Dynamics.

Volker Huck, Po-Chia Chen, Emma-Ruoqi Xu, Alexander Tischer, Ulrike Klemm, Camilo Aponte-Santamaría, Christian Mess, Tobias Obser, Fabian Kutzki, Gesa König and 8 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thrombosis and haemostasis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 4 countries.

Volker Huck *Department of Dermatology and Venereology, Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Po-Chia Chen *Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Emma-Ruoqi Xu *European Molecular Biology Laboratory, Hamburg Unit, Hamburg, Germany.
Alexander TischerDivision of Hematology, Mayo Clinic, Rochester, Minnesota, United States.
Ulrike KlemmDepartment of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Camilo Aponte-SantamaríaMax Planck Tandem Group in Computational Biophysics, University of los Andes, Bogotá, Colombia.
Christian MessDepartment of Dermatology and Venereology, Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Tobias ObserDepartment of Dermatology and Venereology, Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Fabian KutzkiMolecular Biomechanics Group, Heidelberg Institute for Theoretical Studies, Heidelberg, Germany.
Gesa KönigDepartment of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Cécile V DenisLaboratory of Hemostasis, Inflammation and Thrombosis, Institut National de la Santé et de la Recherche Médicale UMR_1176, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
Frauke GräterInterdisciplinary Center for Scientific Computing, Heidelberg University, Heidelberg, Germany.
Matthias WilmannsEuropean Molecular Biology Laboratory, Hamburg Unit, Hamburg, Germany.
Matthew AutonDivision of Hematology, Mayo Clinic, Rochester, Minnesota, United States.
Stefan W SchneiderDepartment of Dermatology and Venereology, Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Reinhard SchneppenheimDepartment of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Janosch HennigStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Maria A BrehmDepartment of Dermatology and Venereology, Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Universität Hamburg · DEUniversity Medical Center Hamburg-Eppendorf · DEEuropean Molecular Biology Laboratory · DEEuropean Molecular Biology Laboratory · DEHeidelberg Institute for Theoretical Studies · DEMayo Clinic · USUniversidad de Los Andes · COUniversité Paris-Saclay · FR

Funding

Structure-Resolved Mechanistic Phenotyping of Von Willebrand DiseaseR01HL146508 · NHLBI · MAYO CLINIC ROCHESTER · PI AUTON, MATTHEW · 2020 to 2023
$1.9M
Thermodynamics of the Conformational Activation of Von Willebrand FactorR01HL109109 · NHLBI · MAYO CLINIC ROCHESTER · PI AUTON, MATTHEW · 2011 to 2015
$1.7M
NHLBI NIH HHS R01 HL109109NHLBI NIH HHS R01 HL146508
6 · The paper itself

Abstract

The multimeric plasma glycoprotein (GP) von Willebrand factor (VWF) is best known for recruiting platelets to sites of injury during primary hemostasis. Generally, mutations in the

Indexed as

Gain of Function MutationGenetic VariationHemostasisHumansPlatelet AggregationPlatelet Glycoprotein GPIIb-IIIa ComplexProtein Domainsvon Willebrand Diseasesvon Willebrand FactorPlatelet Glycoprotein GPIIb-IIIa Complexvon Willebrand Factor

Identifiers

PMID33385180
PMCPMC8828397
OpenAlexW3116427496

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.