Evidence map›Paper›PMID 33385165›Full record

ReviewRadiology. Cardiothoracic imaging2020

Coronary Artery Calcium Scoring: New Insights into Clinical Interpretation-Lessons from the CAC Consortium.

Siegfried Adelhoefer, S M Iftekhar Uddin, Albert D Osei, Olufunmilayo H Obisesan, Michael J Blaha, Omar Dzaye

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Radiology. Cardiothoracic imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Siegfried AdelhoeferJohns Hopkins Ciccarone Center for Prevention of Cardiovascular Disease (S.A., S.M.I.U., A.D.O., O.H.O., M.J.B., O.D.) and Russell H. Morgan Department of Radiology and Radiological Science (O.D.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Medicine, MedStar Union Memorial Hospital, Baltimore, Md (A.D.O.); and Department of Radiology and Neuroradiology, Charité, Berlin, Germany (S.A., O.D.).ORCID 0000-0002-3058-8250
S M Iftekhar UddinJohns Hopkins Ciccarone Center for Prevention of Cardiovascular Disease (S.A., S.M.I.U., A.D.O., O.H.O., M.J.B., O.D.) and Russell H. Morgan Department of Radiology and Radiological Science (O.D.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Medicine, MedStar Union Memorial Hospital, Baltimore, Md (A.D.O.); and Department of Radiology and Neuroradiology, Charité, Berlin, Germany (S.A., O.D.).ORCID 0000-0001-6383-0886
Albert D OseiJohns Hopkins Ciccarone Center for Prevention of Cardiovascular Disease (S.A., S.M.I.U., A.D.O., O.H.O., M.J.B., O.D.) and Russell H. Morgan Department of Radiology and Radiological Science (O.D.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Medicine, MedStar Union Memorial Hospital, Baltimore, Md (A.D.O.); and Department of Radiology and Neuroradiology, Charité, Berlin, Germany (S.A., O.D.).ORCID 0000-0002-3901-0471
Olufunmilayo H ObisesanJohns Hopkins Ciccarone Center for Prevention of Cardiovascular Disease (S.A., S.M.I.U., A.D.O., O.H.O., M.J.B., O.D.) and Russell H. Morgan Department of Radiology and Radiological Science (O.D.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Medicine, MedStar Union Memorial Hospital, Baltimore, Md (A.D.O.); and Department of Radiology and Neuroradiology, Charité, Berlin, Germany (S.A., O.D.).ORCID 0000-0001-7247-5257
Michael J BlahaJohns Hopkins Ciccarone Center for Prevention of Cardiovascular Disease (S.A., S.M.I.U., A.D.O., O.H.O., M.J.B., O.D.) and Russell H. Morgan Department of Radiology and Radiological Science (O.D.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Medicine, MedStar Union Memorial Hospital, Baltimore, Md (A.D.O.); and Department of Radiology and Neuroradiology, Charité, Berlin, Germany (S.A., O.D.).ORCID 0000-0001-5138-9683
Omar DzayeJohns Hopkins Ciccarone Center for Prevention of Cardiovascular Disease (S.A., S.M.I.U., A.D.O., O.H.O., M.J.B., O.D.) and Russell H. Morgan Department of Radiology and Radiological Science (O.D.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Medicine, MedStar Union Memorial Hospital, Baltimore, Md (A.D.O.); and Department of Radiology and Neuroradiology, Charité, Berlin, Germany (S.A., O.D.).ORCID 0000-0001-9483-3510
Johns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronary artery calcium (CAC) is a highly specific marker for coronary atherosclerosis. The CAC Consortium, a multicenter, retrospective, real-world cohort study, was established to investigate the association between CAC and long-term, cause-specific mortality. This review summarizes findings from CAC Consortium studies published between 2016 and 2020, aiming to demystify CAC as a clinical decision-guiding tool and push the limits of who might benefit from CAC in clinical practice. CAC has been shown to effectively stratify cardiovascular risk across ethnicities irrespective of age, sex, and risk factor burden. In comparison to other widely used risk scores, CAC appears to be most consistent in its ability to add to cardiovascular disease (CVD) event prediction. Beyond risk stratification, CAC has been shown to identify high-risk patient subgroups. While currently recommended only for patients at borderline or intermediate risk by the American College of Cardiology/American Heart Association (10-year atherosclerotic CVD event risk, 5% to < 20%), CAC scoring may also provide value in select young patients aged 30-49 years and in low-risk patients with a family history. While new studies emphasize that patients with a CAC greater than or equal to 1000 be considered a distinct patient group, a CAC of 0 has additionally emerged to be a reliable negative risk factor, identifying patients at low risk of both CVD and non-CVD mortality. © RSNA, 2020.

Identifiers

PMID33385165
PMCPMC7757721
OpenAlexW3111345599

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.