Evidence map›Paper›PMID 33385164›Full record

ArticleRadiology. Cardiothoracic imaging2020

5D Flow MRI: A Fully Self-gated, Free-running Framework for Cardiac and Respiratory Motion-resolved 3D Hemodynamics.

Liliana E Ma, Jérôme Yerly, Davide Piccini, Lorenzo Di Sopra, Christopher W Roy, James C Carr, Cynthia K Rigsby, Daniel Kim, Matthias Stuber, Michael Markl

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology. Cardiothoracic imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Fully self-gated dual-venc five-dimensional flow magnetic resonance imaging for simultaneous imaging of the cardiovascular and portal venous systems: A feasibility study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2026
    Article
  7. Motion Mitigation Techniques for Abdominal and Cardiac MR Imaging.Journal of magnetic resonance imaging : JMRI · 2026
    Review
  8. Comparison of free-running whole-heart five-dimensional and four-dimensional flow imaging to standard two-dimensional flow in patients with congenital heart disease.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Third trimester fetal 4D flow MRI with motion correction.Magnetic resonance in medicine · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. 4D flow MRI velocity uncertainty quantification.Magnetic resonance in medicine · 2025
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Liliana E MaDepartments of Radiology, Feinberg School of Medicine (L.E.M., J.C.C., C.K.R., D.K., M.M.) and Biomedical Engineering (L.E.M., J.C.C., D.K., M.M.), Northwestern University, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (J.Y., D.P., L.D.S., C.W.R., M.S.); Center for Biomedical Imaging, Lausanne, Switzerland (J.Y., M.S.); Department of Advanced Clinical Imaging Technology, Siemens Healthineers, Lausanne, Switzerland (D.P.); and Department of Medical Imaging, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill (C.K.R.).ORCID 0000-0001-8834-8519
Jérôme YerlyDepartments of Radiology, Feinberg School of Medicine (L.E.M., J.C.C., C.K.R., D.K., M.M.) and Biomedical Engineering (L.E.M., J.C.C., D.K., M.M.), Northwestern University, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (J.Y., D.P., L.D.S., C.W.R., M.S.); Center for Biomedical Imaging, Lausanne, Switzerland (J.Y., M.S.); Department of Advanced Clinical Imaging Technology, Siemens Healthineers, Lausanne, Switzerland (D.P.); and Department of Medical Imaging, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill (C.K.R.).ORCID 0000-0003-4347-8613
Davide PicciniDepartments of Radiology, Feinberg School of Medicine (L.E.M., J.C.C., C.K.R., D.K., M.M.) and Biomedical Engineering (L.E.M., J.C.C., D.K., M.M.), Northwestern University, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (J.Y., D.P., L.D.S., C.W.R., M.S.); Center for Biomedical Imaging, Lausanne, Switzerland (J.Y., M.S.); Department of Advanced Clinical Imaging Technology, Siemens Healthineers, Lausanne, Switzerland (D.P.); and Department of Medical Imaging, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill (C.K.R.).ORCID 0000-0003-4663-3244
Lorenzo Di SopraDepartments of Radiology, Feinberg School of Medicine (L.E.M., J.C.C., C.K.R., D.K., M.M.) and Biomedical Engineering (L.E.M., J.C.C., D.K., M.M.), Northwestern University, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (J.Y., D.P., L.D.S., C.W.R., M.S.); Center for Biomedical Imaging, Lausanne, Switzerland (J.Y., M.S.); Department of Advanced Clinical Imaging Technology, Siemens Healthineers, Lausanne, Switzerland (D.P.); and Department of Medical Imaging, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill (C.K.R.).ORCID 0000-0003-3426-9457
Christopher W RoyDepartments of Radiology, Feinberg School of Medicine (L.E.M., J.C.C., C.K.R., D.K., M.M.) and Biomedical Engineering (L.E.M., J.C.C., D.K., M.M.), Northwestern University, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (J.Y., D.P., L.D.S., C.W.R., M.S.); Center for Biomedical Imaging, Lausanne, Switzerland (J.Y., M.S.); Department of Advanced Clinical Imaging Technology, Siemens Healthineers, Lausanne, Switzerland (D.P.); and Department of Medical Imaging, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill (C.K.R.).ORCID 0000-0002-3111-8840
James C CarrDepartments of Radiology, Feinberg School of Medicine (L.E.M., J.C.C., C.K.R., D.K., M.M.) and Biomedical Engineering (L.E.M., J.C.C., D.K., M.M.), Northwestern University, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (J.Y., D.P., L.D.S., C.W.R., M.S.); Center for Biomedical Imaging, Lausanne, Switzerland (J.Y., M.S.); Department of Advanced Clinical Imaging Technology, Siemens Healthineers, Lausanne, Switzerland (D.P.); and Department of Medical Imaging, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill (C.K.R.).
Cynthia K RigsbyDepartments of Radiology, Feinberg School of Medicine (L.E.M., J.C.C., C.K.R., D.K., M.M.) and Biomedical Engineering (L.E.M., J.C.C., D.K., M.M.), Northwestern University, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (J.Y., D.P., L.D.S., C.W.R., M.S.); Center for Biomedical Imaging, Lausanne, Switzerland (J.Y., M.S.); Department of Advanced Clinical Imaging Technology, Siemens Healthineers, Lausanne, Switzerland (D.P.); and Department of Medical Imaging, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill (C.K.R.).ORCID 0000-0003-1224-2333
Daniel KimDepartments of Radiology, Feinberg School of Medicine (L.E.M., J.C.C., C.K.R., D.K., M.M.) and Biomedical Engineering (L.E.M., J.C.C., D.K., M.M.), Northwestern University, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (J.Y., D.P., L.D.S., C.W.R., M.S.); Center for Biomedical Imaging, Lausanne, Switzerland (J.Y., M.S.); Department of Advanced Clinical Imaging Technology, Siemens Healthineers, Lausanne, Switzerland (D.P.); and Department of Medical Imaging, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill (C.K.R.).ORCID 0000-0003-2660-8973
Matthias StuberDepartments of Radiology, Feinberg School of Medicine (L.E.M., J.C.C., C.K.R., D.K., M.M.) and Biomedical Engineering (L.E.M., J.C.C., D.K., M.M.), Northwestern University, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (J.Y., D.P., L.D.S., C.W.R., M.S.); Center for Biomedical Imaging, Lausanne, Switzerland (J.Y., M.S.); Department of Advanced Clinical Imaging Technology, Siemens Healthineers, Lausanne, Switzerland (D.P.); and Department of Medical Imaging, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill (C.K.R.).ORCID 0000-0001-9843-2028
Michael MarklDepartments of Radiology, Feinberg School of Medicine (L.E.M., J.C.C., C.K.R., D.K., M.M.) and Biomedical Engineering (L.E.M., J.C.C., D.K., M.M.), Northwestern University, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (J.Y., D.P., L.D.S., C.W.R., M.S.); Center for Biomedical Imaging, Lausanne, Switzerland (J.Y., M.S.); Department of Advanced Clinical Imaging Technology, Siemens Healthineers, Lausanne, Switzerland (D.P.); and Department of Medical Imaging, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill (C.K.R.).
Northwestern University · USCentre d'Imagerie BioMedicale · CHUniversity of Lausanne · CHSiemens (Switzerland) · CH

Funding

Functional Cardiovascular 4D MRI in Congenital Heart DiseaseR01HL115828 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MARKL, MICHAEL, RIGSBY, CYNTHIA K · 2012 to 2021
$5.2M
4D Flow MRI-based assessment of atrial fibrillationF30HL137279 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MA, LILIANA · 2017 to 2020
$189k
NHLBI NIH HHS F30 HL137279NHLBI NIH HHS R01 HL115828
6 · The paper itself

Abstract

purposeTo implement, validate, and apply a self-gated free-running whole-heart five-dimensional (5D) flow MRI framework to evaluate respiration-driven effects on three-dimensional (3D) hemodynamics in a clinical setting. MATERIALS AND

methodsIn this prospective study, a free-running five-dimensional (5D) flow sequence was implemented with 3D radial sampling, self-gating, and a compressed-sensing reconstruction. The 5D flow was evaluated in a pulsatile phantom and adult participants with aortic and/or valvular disease who were enrolled between May and August 2019. Conventional twofold-accelerated four-dimensional (4D) flow of the thoracic aorta with navigator gating was performed as a reference comparison. Continuous parameters were evaluated for parameter normality and were compared between conventional 4D flow and 5D flow using a signed-rank or two-tailed paired

resultsA total of 20 adult participants (mean age, 49 years ± 17 [standard deviation]; 18 men and two women) were included. In vitro 5D flow results showed excellent agreement with conventional 4D flow-derived values (peak and net flow, <7% difference over all quantified planes). Whole-heart 5D flow data were collected in all participants in 7.65 minutes ± 0.35 (acceleration rate = 36.0-76.9) versus 9.88 minutes ± 3.17 for conventional aortic 4D flow. In vivo, 5D flow demonstrated moderate agreement with conventional 4D flow but demonstrated overestimation in net flow and peak velocity (up to 26% and 12%, respectively) in the ascending aorta and underestimation (<12%) in the arch and descending aorta. Respiratory-resolved analyses of caval veins showed significantly increased net and peak flow in the inferior vena cava in end inspiration compared with end expiration, and the opposite trend was shown in the superior vena cava.

conclusionA free-running 5D flow MRI framework consistently captured cardiac and respiratory motion-resolved 3D hemodynamics in less than 8 minutes.

Identifiers

PMID33385164
PMCPMC7755133
OpenAlexW3105964432

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.