Evidence map›Paper›PMID 33385126›Full record

ArticleEClinicalMedicine2021

The evaluation of ENGBD versus PTGBD in high-risk acute cholecystitis: A single-center prospective randomized controlled trial.

Peilei Mu, Yanyan Lin, Xianzhuo Zhang, Yawen Lu, Man Yang, Zijian Da, Long Gao, Ningning Mi, Tianya Li, Ying Liu and 7 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03701464 (Comparison of Clinical Efficacy Between ENGBD and PTGBD in Acute Suppurative Cholecystitis), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03701464 nacompletednot on this map

Comparison of Clinical Efficacy Between ENGBD and PTGBD in Acute Suppurative Cholecystitis: a Single-center, Prospective Randomized Trial

TypeinterventionalSponsorHepatopancreatobiliary Surgery Institute of Gansu ProvinceRan2018 to 2020Enrolled22ConditionsSuccess RateArmsEndoscopic naso-gallbladder drainage, Percutaneous gallbladder drainage
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Peilei MuThe First Clinical Medical School of Lanzhou University, Lanzhou, Gansu, China.
Yanyan LinThe First Clinical Medical School of Lanzhou University, Lanzhou, Gansu, China.
Xianzhuo ZhangThe First Clinical Medical School of Lanzhou University, Lanzhou, Gansu, China.
Yawen LuThe First Clinical Medical School of Lanzhou University, Lanzhou, Gansu, China.
Man YangDepartment of Gastroenterology, Songgang People's Hospital, Shenzhen, Guangdong, China.
Zijian DaThe First Clinical Medical School of Lanzhou University, Lanzhou, Gansu, China.
Long GaoThe First Clinical Medical School of Lanzhou University, Lanzhou, Gansu, China.
Ningning MiThe First Clinical Medical School of Lanzhou University, Lanzhou, Gansu, China.
Tianya LiThe First Clinical Medical School of Lanzhou University, Lanzhou, Gansu, China.
Ying LiuForeign Languages Department of Lanzhou University, Lanzhou, China.
Haiping WangGansu Province Key Laboratory of Biological Therapy and Regenerative Medicine Transformation, Lanzhou, Gansu, China.
Fang WangDepartment of Pathology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Joseph W LeungDivision of Gastroenterology and Hepatology, University of California, Davis Medical Center and Sacramento Veterans Affairs Medical Center, Sacramento, CA, United States.
Ping YueThe First Clinical Medical School of Lanzhou University, Lanzhou, Gansu, China.
Wenbo MengThe First Clinical Medical School of Lanzhou University, Lanzhou, Gansu, China.
Wence ZhouThe First Clinical Medical School of Lanzhou University, Lanzhou, Gansu, China.
Xun LiThe First Clinical Medical School of Lanzhou University, Lanzhou, Gansu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGallbladder drainage plays a key role in the management of acute cholecystitis (AC) patients. Percutaneous transhepatic gallbladder drainage (PTGBD) is commonly used while endoscopic naso-gallbladder drainage (ENGBD) serves as an alternative.

methodsA single center, prospective randomized controlled trial was performed. Eligible AC patients were randomly assigned to ENGBD or PTGBD group. Randomization was a computer-generated list with 1:1 allocation. All patients received cholecystectomy 2-3 months after drainage. The primary endpoint was abdominal pain score, and the intention-to-treat population was analyzed. (ClinicalTrials.gov: NCT03701464).

findingsBetween Oct 1, 2018 and Feb 29, 2020, 22 out of 61 consecutive AC patients were enrolled in the final analysis. The mean abdominal pain scores before drainage, and at 24, 48, and 72 h after drainage in ENGBD were 6.9 ± 1.1, 4.3 ± 1.2, 2.2 ± 0.8 and 1.5 ± 0.5, respectively, while those of PTGBD were 7.4 ± 1.2, 6.2 ± 1.2, 5.3 ± 1.0 and 3.7 ± 0.9; and the mean gallbladder area tenderness scores were 8.4 ± 1.2, 5.7 ± 0.9, 3.5 ± 0.7, 2.5 ± 0.5 for ENGBD and 8.6 ± 0.9, 7.3 ± 1.0, 7.4 ± 0.5, 4.8 ± 0.9 for PTGBD. The mean abdominal pain and gallbladder area tenderness scores of the ENGBD significantly decreased than the PTGBD (group × time interaction

interpretationCompared to PTGBD, ENGBD group presented less pain, better gallbladder pathological grades and less surgical difficulties during cholecystectomy procedures.

fundingNational Natural Science Foundation of China (82060551).

Identifiers

PMID33385126
PMCPMC7772541

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.