Evidence map›Paper›PMID 33385123›Full record

ArticleEClinicalMedicine2021

Proinflammatory cytokines predict the incidence of diabetic peripheral neuropathy over 5 years in Chinese type 2 diabetes patients: A prospective cohort study.

Hangping Zheng, Wanwan Sun, Qi Zhang, Yuanpin Zhang, Lijin Ji, Xiaoxia Liu, Xiaoming Zhu, Hongying Ye, Qian Xiong, Yiming Li and 2 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05577390 (A Physiologic Comparison of Two Approaches to Treating Peripheral Neuropathy), which is not on this map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05577390 narecruitingnot on this mapstarted 2024, after this paper: background citation

A Physiologic Comparison of Two Approaches to Treating Peripheral Neuropathy

TypeinterventionalSponsorLoma Linda UniversityRan2024 to 2027Enrolled40ConditionsPeripheral Neuropathy With Type 2 DiabetesArmsIntraneural Facilitation Therapy Treatment, Standard Physical Therapy Treatment
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Hangping ZhengDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China.
Wanwan SunDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China.
Qi ZhangDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China.
Yuanpin ZhangDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China.
Lijin JiDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China.
Xiaoxia LiuDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China.
Xiaoming ZhuDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China.
Hongying YeDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China.
Qian XiongDepartment of Endocrinology, Shanghai Gonghui Hospital, Shanghai 200041, China.
Yiming LiDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China.
Bin LuDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China.
Shuo ZhangDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China.
Fudan University · CNSecond Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInflammation has been implicated in the pathogenesis of diabetic peripheral neuropathy (DPN) as suggested in various cross-sectional studies. However, more convincing prospective studies in diabetes patients are scarce. Therefore, we aimed to evaluate whether proinflammatory cytokines could predict the incidence of DPN through a prospective study with a five-year follow-up.

methodsWe followed up 315 patients with diabetes who did not have DPN, recruited from five community health centers in Shanghai in 2014, for an average of 5.06 years. Based on the integrity of blood samples, 106 patients were selected to obtain the proinflammatory cytokines. Plasma markers of proinflammatory cytokines at baseline included interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), vascular endothelial growth factor (VEGF), and intercellular adhesion molecule 1 (ICAM-1). Neuropathy was assessed by MSNI at baseline and during follow-up.

findingsAmong the 106 chosen patients, 63 developed DPN after 5.06±1.14 years of follow-up. The baseline plasma levels of TNF-α, IL-6, and ICAM-1 were higher in the neuropathic group (p<0.05). In multivariate models, increased plasma levels of TNF-α (hazard ratio, HR: 8.74 [95% confidence interval, CI: 1.05-72.68];

interpretationIncreased plasma levels of proinflammatory factors, especially TNF-α and ICAM-1, predicted the incidence of DPN over 5 years in Chinese diabetes patients, but larger longitudinal studies are required for confirmation.

fundingNational Natural Science Foundation of China, Shanghai Talent Development Fund Program, Shanghai Shenkang Hospital Developing Center Clinical Scientific and Technological Innovation Program, Shanghai Science and Technology Committee Program, Shanghai General Hospital Program of Chinese traditional and Western medicine combination and Shanghai Municipal Commission of Health and Family Planning Clinical Research Project.

Indexed as

ACR, albumin-to-creatinine ratioALT, alanine aminotransferaseAST, aspartate aminotransferaseDBP, diastolic blood pressureDiabetic peripheral neuropathyDPN, diabetic peripheral neuropathyDSPN, distal sensorimotor polyneuropathyFPG, fasting plasma glucoseHbA1c, glycated hemoglobinHDL-C, high-density lipoprotein cholesterolIL-1RA, interleukin-1 receptor antagonistLDL-C, low-density lipoprotein cholesterolMDRD, Modification of Diet in Renal DiseaseMNSI, Michigan Neuropathy Screening InstrumentNLR, neutrophil-to-lymphocyte ratioPPG, postprandial plasma glucosePredictProinflammatory cytokinesSBP, systolic blood pressureScr, serum creatinineTC, total cholesterolTG, triacylglycerol

Identifiers

PMID33385123
PMCPMC7772538
OpenAlexW3114521760

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.