ArticleiScience2021
Targeting CD38-dependent NAD
Registry-linked trialOpen access · goldAbstract read
In one paragraph
Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06567717 (Feasibility of a Decentralized Double-Blind Randomized Controlled Trial of Zinc and Nicotinamide Riboside for the Treatment of Idiopathic Pulmonary Fibrosis), which is not on this map. Cited by 47 papers.
0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Feasibility of a Decentralized Double-Blind Randomized Controlled Trial of Zinc and Nicotinamide Riboside for the Treatment of Idiopathic Pulmonary Fibrosis
Who cites it
47 citing papers in PubMed, 61 citations in OpenAlex.
- NADBiochemistry and biophysics reports · 2026Article
- Low-Dose Ionizing Radiation and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Review of Recent Evidence and Future Research Directions Toward the Elucidation of a Metabolic, Immunologic, and Signaling Cascade.International journal of molecular sciences · 2026Review
- [Systemic Reprogramming of Cellular Senescence: Coordinated Regulation of Metabolism, Epigenetics, and Proteostasis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Vitronectin metabolically programs profibrotic macrophages in 3D cultures and idiopathic pulmonary fibrosis.Science advances · 2026Article
- Emerging chemical strategies for CD38 inhibition: restoring NADBioorganic & medicinal chemistry · 2026Review
- Activation of the impaired NAMPT/SIRT7/SOD2 axis restores alveolar progenitor cell renewal in idiopathic pulmonary fibrosis.The Journal of clinical investigation · 2026Article
- Injectable antifibrotic drug-loaded hydrogels reduce fibrosis and restore myogenesis by enhancing mitochondrial metabolism and cell mechanics in an in vitro coculture model.Materials today. Bio · 2026Article
- Role of hypertrophic adipocytes, collagen VI, and CD38 in adipose tissue fibrosis in obesity.Scientific reports · 2026Article
- Regulating the regulators via targeting CD38 in the tumor microenvironment.Frontiers in immunology · 2026Review
- Elucidating the role of IgA plasma cells and PECAM1-CD38 interaction in intestinal fibrosis: a single-cell RNA sequencing analysis in Crohn's disease.BMC gastroenterology · 2025Article
- Simultaneous onset of systemic sclerosis and light chain amyloidosis: the first report of a case report and review of the literature.Rheumatology international · 2025Review
- Spatiotemporal analysis of Crohn's disease reveals PECAM2 signaling at the basis of the inflammation-to-fibrosis transition.Journal of Crohn's & colitis · 2025Article
- Overcoming resistance to immunotherapy by targeting CD38 in human tumor explants.Cell reports. Medicine · 2025Article
- The role of NADnpj metabolic health and disease · 2025Review
- Article
- Role of epigenetics in corneal health and disease.Progress in retinal and eye research · 2025Review
- Inhibition of CD38 enzyme activity on engrafted human immune cells enhances NAD+ metabolism and inhibits inflammation in anFrontiers in immunology · 2025Article
- Endothelial CD38-induced endothelial-to-mesenchymal transition is a pivotal driver in pulmonary fibrosis.Cellular and molecular life sciences : CMLS · 2024Article
- Article
- CD38 in SLE CD4 T cells promotes CaNature communications · 2024Article
Corrections and comments
- Commented on by
Authors and funding
21 authors at 4 institutions in 1 country.
Bo ShiNorthwestern Scleroderma Program, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Wenxia WangNorthwestern Scleroderma Program, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Benjamin KormanNorthwestern Scleroderma Program, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Li KaiNorthwestern Scleroderma Program, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Qianqian WangNorthwestern Scleroderma Program, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Jun WeiNorthwestern Scleroderma Program, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Swarna BaleNorthwestern Scleroderma Program, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Roberta Goncalves MarangoniNorthwestern Scleroderma Program, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Swati BhattacharyyaNorthwestern Scleroderma Program, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Stephen MillerDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Dan XuDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Mahzad AkbarpourDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Paul ChereshDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Daniele ProccissiDepartment of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Demirkan GurselPathology Core Facility, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Jair Machado Espindola-NettoDepartment of Anesthesiology and Kogod Center on Aging, Mayo Clinic, Rochester 55905 MN, USA.
Claudia C S ChiniDepartment of Anesthesiology and Kogod Center on Aging, Mayo Clinic, Rochester 55905 MN, USA.
Guilherme C de OliveiraDepartment of Anesthesiology and Kogod Center on Aging, Mayo Clinic, Rochester 55905 MN, USA.
Johann E GudjonssonDepartment of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA.
Eduardo N ChiniDepartment of Anesthesiology and Kogod Center on Aging, Mayo Clinic, Rochester 55905 MN, USA.
John VargaNorthwestern Scleroderma Program, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Northwestern University · USMayo Clinic · USWinnMed · USUniversity of Michigan–Ann Arbor · US
Funding
University of Michigan Skin Biology and Diseases Resource-based CenterP30AR075043 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Johann Eli Gudjonsson · 2019 to 2026
$6.6MThe Sir2-p53-IGF Link in Mammalian Life-Span ControlR01AG026094 · NIA · UNIVERSITY OF VIRGINIA · PI CHINI, EDUARDO N · 2006 to 2016
$3.8MTherapeutic implication of CD38 in CLLR01CA233790 · NCI · MAYO CLINIC JACKSONVILLE · PI CHINI, EDUARDO N · 2019 to 2023
$3.0MRole of CD38 in NAD metabolism: from the basic biology of aging to translationR01AG058812 · NIA · MAYO CLINIC ROCHESTER · PI CHINI, EDUARDO N · 2018 to 2022
$2.0MContribution of Adipocytes and Adipose Secreted Factors to Fibrosis in Systemic SclerosisK08AR070285 · NIAMS · UNIVERSITY OF ROCHESTER · PI KORMAN, BENJAMIN DOUGLAS · 2016 to 2020
$787kSirtuins: novel determinants and therapeutic target in systemic sclerosisR56AG054207 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI VARGA, JOHN · 2016 to 2016
$520kTargeting NAD metabolism to treat systemic sclerosisR21AR074523 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHINI, EDUARDO N, VARGA, JOHN · 2018 to 2019
$396kRegulation of the Profibrotic Mechanisms of MACRO+ Myeloid Cells in SclerodermaR21AR073371 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MILLER, STEPHEN D, VARGA, JOHN · 2018 to 2019
$382kNCI NIH HHS R01 CA233790NIAMS NIH HHS K08 AR070285NIAMS NIH HHS P30 AR075043NIAMS NIH HHS R21 AR073371NIAMS NIH HHS R21 AR074523NIA NIH HHS R01 AG026094NIA NIH HHS R01 AG058812NIA NIH HHS R56 AG054207
Abstract
The processes underlying synchronous multiple organ fibrosis in systemic sclerosis (SSc) remain poorly understood. Age-related pathologies are associated with organismal decline in nicotinamide adenine dinucleotide (NAD
Indexed as
Human MetabolismImmunologyMolecular Biology
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
NCT06567717ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.