ArticleBone reports2021
The investigation of bone fracture healing under intramembranous and endochondral ossification.
Article in Bone reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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Who cites it
35 citing papers in PubMed, 76 citations in OpenAlex.
- Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio-Interactive Materials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Sustainable Valorization of Biogenic Waste for Bone Repair and Regeneration: A Comprehensive Review of Eggshell and Aquatic Biomaterials.Journal of functional biomaterials · 2026Review
- Hierarchical micro-/nanostructured hydroxyapatite scaffolds promote osteoporotic bone regeneration via activation of hedgehog and HIF-1α signaling.Bioactive materials · 2026Article
- Could alteration in the vacuum phenomenon rather than its presence be a sign of spinal instability?European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Biologics for bone regeneration: advances in cell, protein, gene, and mRNA therapies.Bone research · 2026Review
- Current state of bioceramic bone repair materials in immune regulation: a review.Frontiers of medicine · 2025Review
- An In Silico Model to Examine the Interaction Between Implant Degradation and Fracture Healing Under Mechanical Loading.Annals of biomedical engineering · 2025Article
- Cartilage-SpecificBiomedicines · 2025Article
- Individual muscle strengths in rehabilitation outcomes of distal radius fracture.Journal of neuroengineering and rehabilitation · 2025Article
- Tuning the trabecular orientation of Voronoi-based scaffold to optimize the micro-environment for bone healing.Biomechanics and modeling in mechanobiology · 2025Article
- Recent Advances in Silk Fibroin-Based Composites for Bone Repair Applications: A Review.Polymers · 2025Review
- Review
- Electro-spun piezoelectric PLLA smart composites as a scaffold on bone fracture: A review.Regenerative therapy · 2025Review
- Communication between endothelial cells and osteoblasts in regulation of bone homeostasis: Notch players.Stem cell research & therapy · 2025Review
- Healing of Comminuted Fractures of Long Bones in Dogs.Animals : an open access journal from MDPI · 2025Article
- Nanomaterial application for protein delivery in bone regeneration therapy.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025Review
- Treatment of Bone Defects and Nonunion via Novel Delivery Mechanisms, Growth Factors, and Stem Cells: A Review.ACS biomaterials science & engineering · 2024Review
- Article
- A computational model that integrates unrestricted callus growth, mechanobiology, and angiogenesis can predict bone healing in rodents.Scientific reports · 2024Article
- Exosome-Integrated Hydrogels for Bone Tissue Engineering.Gels (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After trauma, fractured bone starts healing directly through bone union or indirectly through callus formation process. Intramembranous and endochondral ossification are two commonly known mechanisms of indirect healing. The present study investigated the bone fracture healing under intramembranous and endochondral ossification by developing theoretical models in conjunction with performing a series of animal experiments. Using experimentally determined mean bone densities in sheep tibia stabilized by the Locking Compression Plate (LCP) fixation system, the research outcomes showed that intramembranous and endochondral ossification can be described by Hill Function with two unique sets of function parameters in mechanical stimuli mediated fracture healing. Two different thresholds exist within the range of mechanical simulation index which could trigger significant intramembranous and endochondral ossification, with a relatively higher bone formation rate of endochondral ossification than that of intramembranous ossification. Furthermore, the increase of flexibility of the LCP system and the use of titanium LCP could potentially promote uniform bone formation across the fracture gap, ultimately better healing outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.