Evidence map›Paper›PMID 33384823›Full record

ArticleJournal of dental sciences2021

Questionnaire survey of angiogenesis inhibitor-related oral complications based on a nation-wide study in Japan.

Shin-Ichi Yamada, Hiroshi Kurita, Akira Tanaka, Masaru Miyata, Yoshinari Morimoto, Akira Yamaguchi, Souichi Yanamoto, Hiromasa Yoshikawa, Yutaka Imai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Shin-Ichi YamadaDepartment of Dentistry and Oral Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Hiroshi KuritaDepartment of Dentistry and Oral Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Akira TanakaCommittee for Survey, Planning, Promotion of Guidelines, and Projects, Japanese Society of Dentistry for Medically Compromised Patient, Kita-ku, Japan.
Masaru MiyataCommittee for Survey, Planning, Promotion of Guidelines, and Projects, Japanese Society of Dentistry for Medically Compromised Patient, Kita-ku, Japan.
Yoshinari MorimotoCommittee for Survey, Planning, Promotion of Guidelines, and Projects, Japanese Society of Dentistry for Medically Compromised Patient, Kita-ku, Japan.
Akira YamaguchiCommittee for Survey, Planning, Promotion of Guidelines, and Projects, Japanese Society of Dentistry for Medically Compromised Patient, Kita-ku, Japan.
Souichi YanamotoCommittee for Survey, Planning, Promotion of Guidelines, and Projects, Japanese Society of Dentistry for Medically Compromised Patient, Kita-ku, Japan.
Hiromasa YoshikawaCommittee for Survey, Planning, Promotion of Guidelines, and Projects, Japanese Society of Dentistry for Medically Compromised Patient, Kita-ku, Japan.
Yutaka ImaiDepartment of Oral and Maxillofacial Surgery, Dokkyo Medical University School of Medicine, Mibu, Japan.
Nippon Dental University · JPShinshu University · JPIshikawa Prefectural Central Hospital · JPJapanese Society of Medical Oncology · JPKanagawa Dental University · JPNagasaki University · JPNational Kyushu Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background/purposeThe prevalence of oral adverse events and dental treatments related complications during the molecular targeted drugs therapy remains unclear. The purpose of this study was to investigate the contents of dental treatment-related complications in Japanese patients during molecular targeted therapy. MATERIALS AND

methodsThe nation-wide survey of dental treatment related complications was performed by the Japanese Society of Dentistry for Medically Compromised Patient as retrospective cohort study.

resultsAmong 212 dentists, 87.3% recognized the possibility of dental treatments related complications in patients with angiogenesis inhibitors. The oral adverse events including dental treatment-related complications associated with angiogenesis inhibitors were 79 cases. In patients with angiogenesis inhibitors, 73.4% of patients were administrated with bevacizumab. The average administration period of angiogenesis inhibitors was 14.0 ± 10.0 months. As the dental treatment related complications, delayed wound healing was most commonly seen in 45 patients (57.0%), followed by osteonecrosis of the jaw in 25 (31.6%). The triggered factor of complications was tooth extraction in 51 cases (96.2%).

conclusionThe extraction of the tooth with pre-existing inflammation may be suggested as one of risk factors for angiogenesis inhibitor-related dental treatment complications.

Indexed as

Angiogenesis inhibitorHemorrhageOral complicationOsteonecrosis of the jawVEGF

Identifiers

PMID33384823
PMCPMC7770245
OpenAlexW3011089441

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.