ArticleJournal of dental sciences2021
Overexpression of sprouty 1 protein in human oral squamous cell carcinogenesis.
Article in Journal of dental sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Suppression of Spry1 reduces HIF1α-dependent glycolysis and impairs angiogenesis in BRAF-mutant cutaneous melanoma.Journal of experimental & clinical cancer research : CR · 2025Article
- Sprouty 4 expression in human oral squamous cell carcinogenesis.Journal of dental sciences · 2023Article
- Overexpression of transient receptor potential melastatin 6 during human oral squamous cell carcinogenesis.Journal of dental sciences · 2023Article
- Mammalian tumor-like organs. 2. Mammalian adipose has many tumor features and obesity is a tumor-like process.Infectious agents and cancer · 2022Review
- Expression of Orai1 and STIM1 in human oral squamous cell carcinogenesis.Journal of dental sciences · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
abstract background/purposeSprouty (SPRY) has four isoforms, SPRY1-4, and its deficiency produces haphazard 'sprouting' of tracheal tubules. This study investigated SPRY1 protein expression in human oral potentially malignant disorders (OPMDs) and oral squamous cell carcinomas (OSCCs). MATERIALS AND
methods90 OSCCs, 10 OPMDs with malignant transformation (MT), 17 OPMDs without MT, and six normal oral mucosa (NOM) tissue samples were subjected to immunohistochemical staining. Three human oral cancer cell lines (OCCLs), an oral precancer cell line (DOK), and a primary culture of normal oral keratinocytes (HOK) were used for western blotting.
resultsSignificantly increased expression of SPRY1 protein from NOM and OPMD without MT to OSCC was observed. The protein expressions of SPRY1 in OCCLs were significantly enhanced as compared with DOK and HOK. Increased phosphor/total-ERK expression was observed in OCCLs as compared with HOK. A significantly increased SPRY1 protein level was noted in OPMDs with MT as compared with those without MT, in addition to a significant increase in DOK in comparison with HOK.
conclusionOur results indicated that overexpression of SPRY1 protein is potentially associated with human oral squamous cell carcinogenesis.
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