Evidence map›Paper›PMID 33384606›Full record

SynthesisFrontiers in physiology2020

Non-invasive Autonomic Neuromodulation Is Opening New Landscapes for Cardiovascular Diseases.

Mingxian Chen, Songyun Wang, Xuping Li, Lilei Yu, Hui Yang, Qiming Liu, Jianjun Tang, Shenghua Zhou

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mingxian ChenDepartment of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, China.
Songyun WangDepartment of Cardiology, Renmin Hospital, Wuhan University, Wuhan, China.
Xuping LiDepartment of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, China.
Lilei YuDepartment of Cardiology, Renmin Hospital, Wuhan University, Wuhan, China.
Hui YangDepartment of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, China.
Qiming LiuDepartment of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, China.
Jianjun TangDepartment of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, China.
Shenghua ZhouDepartment of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, China.
Central South University · CNSecond Xiangya Hospital of Central South University · CNWuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autonomic imbalance plays a crucial role in the genesis and maintenance of cardiac disorders. Approaches to maintain sympatho-vagal balance in heart diseases have gained great interest in recent years. Emerging therapies However, certain types of emerging therapies including direct electrical stimulation and nerve denervation require invasive implantation of a generator and a bipolar electrode subcutaneously or result in autonomic nervous system (ANS) damage, inevitably increasing the risk of complications. More recently, non-invasive neuromodulation approaches have received great interest in ANS modulation. Non-invasive approaches have opened new fields in the treatment of cardiovascular diseases. Herein, we will review the protective roles of non-invasive neuromodulation techniques in heart diseases, including transcutaneous auricular vagus nerve stimulation, electromagnetic field stimulation, ultrasound stimulation, autonomic modulation in optogenetics, and light-emitting diode and transcutaneous cervical vagus nerve stimulation (gammaCore).

Indexed as

autonomic nervous systemcardiovascular diseaseheartneuromadulationnon-invasive

Identifiers

PMID33384606
PMCPMC7769808
OpenAlexW3112166996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.