Evidence map›Paper›PMID 33384596›Full record

ArticleFrontiers in pharmacology2020

Enhanced Bioavailability of Boswellic Acid by

K Reeta Vijayarani, Manoj Govindarajulu, Sindhu Ramesh, Mansour Alturki, Mohammed Majrashi, Ayaka Fujihashi, Mohammed Almaghrabi, N Kirubakaran, Jun Ren, R Jayachandra Babu and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

K Reeta VijayaraniDepartment of Pharmaceutics, Periyar College of Pharmaceutical Sciences, Tiruchirappalli, India.
Manoj GovindarajuluDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, United States.
Sindhu RameshDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, United States.
Mansour AlturkiDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, United States.
Mohammed MajrashiDepartment of Pharmacology, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia.
Ayaka FujihashiDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, United States.
Mohammed AlmaghrabiDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, United States.
N KirubakaranDepartment of Pharmaceutics, Periyar College of Pharmaceutical Sciences, Tiruchirappalli, India.
Jun RenSchool of Pharmacy, University of Wyoming College of Health Sciences, Laramie, WY, United States.
R Jayachandra BabuDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, United States.
Forrest SmithDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, United States.
Timothy MooreDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, United States.
Muralikrishnan DhanasekaranDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, United States.
Auburn University · USImam Abdulrahman Bin Faisal University · SAIndian Institute of Management Tiruchirappalli · INJeddah University · SAPeriyar University · INUniversity of Wyoming · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic inflammation is a key culprit factor in the onset and progression of several diseases. Novel and pharmacologically effective therapeutic approaches are needed for new treatment remedy or improved pharmacokinetics and pharmacodynamics for existing synthetic drugs, in particular natural products. Boswellic acids are well-known natural products, with capacity to effectively retard inflammation without severe adverse effects. However, the therapeutic use of Boswellic acids are greatly hindered by its poor pharmacokinetic properties. Co-administration strategies that facilitate the oral absorption and distribution of Boswellic acids should lead to a safe and more effective use of this product prophylactically and therapeutically in inflammatory disorders. In this study, we examined the effect of

Indexed as

anti-inflammatorybioavailabilityboswellic acidcomputational analysisnatural productsPiper longum extract

Identifiers

PMID33384596
PMCPMC7770183
OpenAlexW3112046135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.