ArticleAJNR. American journal of neuroradiology2021
Glioma-Induced Disruption of Resting-State Functional Connectivity and Amplitude of Low-Frequency Fluctuations in the Salience Network.
Article in AJNR. American journal of neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Frequency-specific resting state fMRI features in gliomas.Journal of neuro-oncology · 2026Article
- Relationship between functional network integrity, cognition and fatigue at long-term follow-up in patients with IDH-mutated gliomas.Frontiers in human neuroscience · 2026Article
- Structural-functional fingerprinting for abnormalities investigation in glioma patients.Scientific reports · 2025Article
- Machine learning of whole-brain resting-state fMRI signatures for individualized grading of frontal gliomas.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
- Cortical myelin and thickness mapping provide insights into whole-brain tumor burden in diffuse midline glioma.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Article
- Structural alterations of the salience network in patients with insular glioma.Brain and behavior · 2023Article
- Neuroimaging and Neurocognitive Outcomes in Older Patients with Multiple Myeloma Treated with Chemotherapy and Autologous Stem Cell Transplantation.Research square · 2023Article
- Hemodynamic and metabolic correspondence of resting-state voxel-based physiological metrics in healthy adults.NeuroImage · 2022Article
- Altered regional homogeneity in patients with ovarian cancer treated with chemotherapy: a resting state fMRI study.Brain imaging and behavior · 2022Article
- What Can Resting-State fMRI Data Analysis Explain about the Functional Brain Connectivity in Glioma Patients?Tomography (Ann Arbor, Mich.) · 2022Review
- Alternations and Applications of the Structural and Functional Connectome in Gliomas: A Mini-Review.Frontiers in neuroscience · 2022Review
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
background and purposeCognitive challenges are prevalent in survivors of glioma, but their neurobiology is incompletely understood. The purpose of this study was to investigate the effect of glioma presence and tumor characteristics on resting-state functional connectivity and amplitude of low-frequency fluctuations of the salience network, a key neural network associated with cognition. MATERIALS AND
methodsSixty-nine patients with glioma (mean age, 48.74 [SD, 14.32] years) who underwent resting-state fMRI were compared with 31 healthy controls (mean age, 49.68 [SD, 15.54] years). We identified 4 salience network ROIs: left/right dorsal anterior cingulate cortex and left/right anterior insula. Average salience network resting-state functional connectivity and amplitude of low-frequency fluctuations within the 4 salience network ROIs were computed.
resultsPatients with gliomas showed decreased overall salience network resting-state functional connectivity (
conclusionsBy demonstrating decreased resting-state functional connectivity and an increased amplitude of low-frequency fluctuations related to the salience network in patients with glioma, this study adds to our understanding of the neurobiology underpinning observable cognitive deficits in these patients. In addition to more conventional functional connectivity, amplitude of low-frequency fluctuations is a promising functional-imaging biomarker of tumor-induced vascular and neural pathology.
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