Evidence map›Paper›PMID 33384291›Full record

Observational studyAJNR. American journal of neuroradiology2021

Involvement of the Spinal Cord in Primary Mitochondrial Disorders: A Neuroimaging Mimicker of Inflammation and Ischemia in Children.

C A P F Alves, A Goldstein, S R Teixeira, J S Martin-Saavedra, I P de Barcelos, G Fadda, L Caschera, M Kidd, F G Gonçalves, E M McCormick and 4 more

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in AJNR. American journal of neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Advancing the neuroimaging diagnosis and understanding of mitochondrial disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 4 countries.

C A P F AlvesFrom the Division of Neuroradiology, Department of Radiology (C.A.P.F.A., S.R.T., J.S.M.S., L.C., F.G.G., A.V., G.Z.) alvesc@email.chop.edu.ORCID 0000-0001-5877-9086
A GoldsteinDivision of Human Genetics, Department of Pediatrics (A.G., E.M.M., M.J.F., Z.Z.-C.), Mitochondrial Medicine Frontier Program.ORCID 0000-0001-6593-5905
S R TeixeiraFrom the Division of Neuroradiology, Department of Radiology (C.A.P.F.A., S.R.T., J.S.M.S., L.C., F.G.G., A.V., G.Z.).ORCID 0000-0001-5845-058X
J S Martin-SaavedraFrom the Division of Neuroradiology, Department of Radiology (C.A.P.F.A., S.R.T., J.S.M.S., L.C., F.G.G., A.V., G.Z.).ORCID 0000-0002-4197-5424
I P de BarcelosDivision of Human Genetics (I. P.d.B.), Department of Pediatrics, Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.ORCID 0000-0002-3843-4520
G FaddaDepartments of Neurology (G.F.).ORCID 0000-0001-9658-815X
L CascheraFrom the Division of Neuroradiology, Department of Radiology (C.A.P.F.A., S.R.T., J.S.M.S., L.C., F.G.G., A.V., G.Z.).ORCID 0000-0002-2563-9930
M KiddCentre for Statistical Consultation (M.K.), University of Stellenbosch, South Africa.ORCID 0000-0002-4887-7296
F G GonçalvesFrom the Division of Neuroradiology, Department of Radiology (C.A.P.F.A., S.R.T., J.S.M.S., L.C., F.G.G., A.V., G.Z.).ORCID 0000-0002-8889-9879
E M McCormickDivision of Human Genetics, Department of Pediatrics (A.G., E.M.M., M.J.F., Z.Z.-C.), Mitochondrial Medicine Frontier Program.ORCID 0000-0002-5478-8046
M J FalkDivision of Human Genetics, Department of Pediatrics (A.G., E.M.M., M.J.F., Z.Z.-C.), Mitochondrial Medicine Frontier Program.ORCID 0000-0002-1723-6728
Z Zolkipli-CunninghamDivision of Human Genetics, Department of Pediatrics (A.G., E.M.M., M.J.F., Z.Z.-C.), Mitochondrial Medicine Frontier Program.ORCID 0000-0002-0743-8879
A VossoughFrom the Division of Neuroradiology, Department of Radiology (C.A.P.F.A., S.R.T., J.S.M.S., L.C., F.G.G., A.V., G.Z.).ORCID 0000-0003-1346-427X
G ZuccoliFrom the Division of Neuroradiology, Department of Radiology (C.A.P.F.A., S.R.T., J.S.M.S., L.C., F.G.G., A.V., G.Z.).ORCID 0000-0001-9734-8035
Anna Needs Neuroblastoma Answers · USMRC Mitochondrial Biology Unit · GBChildren's Hospital of Philadelphia · USFaculty of 1000 (United Kingdom) · GBFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITGirls Incorporated · USStellenbosch University · ZA

Funding

Primary Mitochondrial Disease Expert Curation PanelU24HD093483 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI FALK, MARNI J, GAI, XIAOWU · 2017 to 2023
$2.2M
NICHD NIH HHS U24 HD093483Wellcome Trust
6 · The paper itself

Abstract

background and purposeLittle is known about imaging features of spinal cord lesions in mitochondrial disorders. The aim of this research was to assess the frequency, imaging features, and pathogenic variants causing primary mitochondrial disease in children with spinal cord lesions. MATERIALS AND

methodsThis retrospective analysis included patients seen at Children's Hospital of Philadelphia between 2000 and 2019 who had a confirmed diagnosis of a primary (genetic-based) mitochondrial disease and available MR imaging of the spine. The MR imaging included at least both sagittal and axial fast spin-echo T2-weighted images. Spine images were independently reviewed by 2 neuroradiologists. Location and imaging features of spinal cord lesions were correlated and tested using the Fisher exact test.

resultsOf 119 children with primary mitochondrial disease in whom MR imaging was available, only 33 of 119 (28%) had available spine imaging for reanalysis. Nineteen of these 33 individuals (58%) had evidence of spinal cord lesions. Two main patterns of spinal cord lesions were identified: group A (12/19; 63%) had white ± gray matter involvement, and group B (7/19; 37%) had isolated gray matter involvement. Group A spinal cord lesions were similar to those seen in patients with neuromyelitis optica spectrum disorder, multiple sclerosis, anti-myelin oligodendrocyte glycoprotein-IgG antibody disease, and leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation. Group B patients had spinal cord findings similar to those that occur with ischemia and viral infections. Significant associations were seen between the pattern of lesions (group A versus group B) and the location of lesions in cervical versus thoracolumbar segments, respectively (

conclusionsSpinal cord lesions are frequently observed in children with primary mitochondrial disease and may mimic more common causes such as demyelination and ischemia.

Indexed as

ChildChild, PreschoolDiagnosis, DifferentialFemaleHumansInfantInflammationIschemiaMagnetic Resonance ImagingMaleMitochondrial DiseasesNeuroimagingRetrospective StudiesSpinal CordSpinal Cord Diseases

Identifiers

PMID33384291
PMCPMC7872189
OpenAlexW3115339387

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.