ArticleReproductive biomedicine online2021
Risks associated with cryopreserved semen in a human sperm bank during and after the COVID-19 pandemic.
Article in Reproductive biomedicine online, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Comparative genetic analysis of blood and semen samples in sperm donors from Hunan, China.Annals of medicine · 2025Article
- Investigating the mode of transmission of COVID-19 through genital secretions, semen, the birth canal, and lactation: A systematic review.Journal of education and health promotion · 2024Article
- The impact of the COVID-19 pandemic on semen quality of uninfected men.Basic and clinical andrology · 2023Article
- Corona and Reproduction, or Why the Corona Vaccination Does Not Result in Infertility.Geburtshilfe und Frauenheilkunde · 2022Article
- Review
- The Impact of SARS-CoV-2 on Sperm Cryostorage, Theoretical or Real Risk?Medicina (Kaunas, Lithuania) · 2021Review
- Severe Acute Respiratory Syndrome Coronavirus 2 and Male Reproduction: Relationship, Explanations, and Clinical Remedies.Frontiers in physiology · 2021Review
- The impact of COVID-19 on the male reproductive tract and fertility: A systematic review.Arab journal of urology · 2021Review
- Evaluation of inactivated COVID-19 vaccine on semen parameters in reproductive-age males: a retrospective cohort study.Asian journal of andrologyArticle
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Authors and funding
16 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
research questionWhat are the risks associated with cryopreserved semen collected during and after the coronavirus disease 2019 (COVID-19) pandemic wave in Wuhan, China?
designRetrospective cohort study involving young adult men who were qualified sperm donors at the Hunan Province Human Sperm Bank (China) during the pandemic wave (1 January 2020 to 30 January 2020) and after the wave and return to work (7 April 2020 to 30 May 30 2020). One hundred paired semen and blood specimens from 100 donors were included. One-step single-tube nested quantitative real-time polymerase chain reaction (OSN-qRT-PCR) was used to detect SARS-CoV-2. Moreover, to control the unacceptable risk of false-negative results, a second round of screening was performed with pooled RNA from negative semen samples using crystal digital PCR (cd-PCR).
resultsFor individual blood and semen samples, the target genes, namely the nucleocapsid protein (N) and open reading frame (ORF-1ab) genes, tested negative in all of the 100 paired samples. Further, as per cd-PCR results, there were >20,000 droplets per well in the RNA for each combined sample and no positive droplets were present for either of the aforementioned target genes. A total of 100 paired semen and blood samples from these two groups tested negative for SARS-CoV-2.
conclusionsCryopreserved semen at the Hunan Province Human Sperm Bank during and after the COVID-19 pandemic wave was free of SARS-CoV-2 and was judged safe for external use in the future.
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