Evidence map›Paper›PMID 33384214›Full record

ReviewTrends in cognitive sciences2021

Neural Computations of Threat.

Ifat Levy, Daniela Schiller

Abstract readReview
In one paragraph

Review in Trends in cognitive sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  16. Hooking the Self Onto the Past: How Positive Autobiographical Memory Retrieval Benefits People With Social Anxiety.Clinical psychological science : a journal of the Association for Psychological Science · 2024
    Article
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  20. The Human Affectome.Neuroscience and biobehavioral reviews · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ifat LevyDepartments of Comparative Medicine, Neuroscience, and Psychology, Yale University, New Haven, CT, USA. Electronic address: ifat.Levy@yale.edu.
Daniela SchillerDepartment of Psychiatry, Department of Neuroscience, and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: daniela.schiller@mssm.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Individual differences in decision making under uncertaintyR01MH118215 · NIMH · YALE UNIVERSITY · PI LEVY, IFAT · 2019 to 2023
$3.4M
Fear learning and reconsolidation after trauma exposure a computational approachR01MH105535 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HARPAZ-ROTEM, ILAN, SCHILLER, DANIELA · 2015 to 2019
$2.4M
NCATS NIH HHS UL1 TR001863NIMH NIH HHS R01 MH105535NIMH NIH HHS R01 MH118215
6 · The paper itself

Abstract

A host of learning, memory, and decision-making processes form the individual's response to threat and may be disrupted in anxiety and post-trauma psychopathology. Here we review the neural computations of threat, from the first encounter with a dangerous situation, through learning, storing, and updating cues that predict it, to making decisions about the optimal course of action. The overview highlights the interconnected nature of these processes and their reliance on shared neural and computational mechanisms. We propose an integrative approach to the study of threat-related processes, in which specific computations are studied across the various stages of threat experience rather than in isolation. This approach can generate new insights about the evolution, diagnosis, and treatment of threat-related psychopathology.

Indexed as

Extinction, PsychologicalFearAnxiety DisordersHumansLearningMemoryamygdalaanxietyBayesian inferenceextinctionfear conditioningprefrontal cortexPTSDreconsolidationreinforcement learningstriatumuncertaintyvalue

Identifiers

PMID33384214
PMCPMC8084636

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.