Evidence map›Paper›PMID 33383970›Full record

SynthesisInternational journal of environmental research and public health2020

Association between Gene Polymorphisms of Vitamin D Receptor and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Qian Zhou, Shiwu Wen, Miao Liu, Sulei Zhang, Xin Jin, Aizhong Liu

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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  9. Review
  10. The Significance ofDiagnostics (Basel, Switzerland) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qian ZhouDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078, China.
Shiwu WenOMNI Research Group, Ottawa Hospital Research Institute, Ottawa, ON K1H 8M5, Canada.
Miao LiuDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078, China.
Sulei ZhangDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078, China.
Xin JinDepartment of Maternal and Child Health, Xiangya School of Public Health, Central South University, Changsha 410078, China.
Aizhong LiuDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Studies on the association between Vitamin D receptor gene polymorphism and gestational diabetes mellitus have been inconsistent. The aim of this study was to summarize available evidence on the association between polymorphisms of Vitamin D receptor genes and susceptibility to gestational diabetes mellitus. (2) Methods: We searched databases of PubMed, Web of Science, Embase, China national knowledge infrastructure (CNKI), China science and technology journal database (VIP), and Wanfang Data for relevant articles. A systematic review and a meta-analysis were done to compare the distribution of Vitamin D receptor gene polymorphisms in gestational diabetes mellitus patients with those in controls using allelic, codominant, dominant, and recessive models. (3) Results: A total of eight eligible articles were included in the systematic review and of them, six articles were included in the meta-analysis. The vitamin D receptor gene rs7975232 polymorphism was associated with gestational diabetes mellitus under the allelic model (odds ratio = 1.28, 95% confidence interval 1.06-1.56), codominant model (CC vs. AA odds ratio = 1.97, 95% confidence interval 1.28-3.05), and recessive model (odds ratio = 1.83, 95% confidence interval 1.27-2.64) in the case of low heterogeneity. High heterogeneity existed in studies on the association of vitamin D receptor genes

Indexed as

Diabetes, GestationalReceptors, CalcitriolChinaCross-Sectional StudiesFemaleGenetic Predisposition to DiseaseHumansPolymorphism, GeneticPregnancyProspective StudiesReceptors, CalcitriolVDR protein, humangene polymorphismgestational diabetes mellitusvitamin D receptor genes

Identifiers

PMID33383970
PMCPMC7794905

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.