Evidence map›Paper›PMID 33383950›Full record

ArticleInternational journal of molecular sciences2020

Adult Renal Stem/Progenitor Cells Can Modulate T Regulatory Cells and Double Negative T Cells.

Claudia Curci, Angela Picerno, Nada Chaoul, Alessandra Stasi, Giuseppe De De Palma, Rossana Franzin, Paola Pontrelli, Giuseppe Castellano, Giovanni B Pertosa, Luigi Macchia and 5 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Claudia CurciNephrology, Dialysis and Transplantation Unit, DETO, University of Bari "Aldo Moro", 70124, Bari, Italy.
Angela PicernoNephrology, Dialysis and Transplantation Unit, DETO, University of Bari "Aldo Moro", 70124, Bari, Italy.
Nada ChaoulAllergology Unit, DETO, University of Bari "Aldo Moro", 70124, Bari, Italy.ORCID 0000-0002-7844-7377
Alessandra StasiNephrology, Dialysis and Transplantation Unit, DETO, University of Bari "Aldo Moro", 70124, Bari, Italy.ORCID 0000-0003-3652-3623
Giuseppe De De PalmaInstitutional BioBank, Experimental Oncology and Biobank Management Unit, IRCCS Istituto Tumori "Giovanni Paolo II", 70124, Bari, Italy.
Rossana FranzinNephrology, Dialysis and Transplantation Unit, DETO, University of Bari "Aldo Moro", 70124, Bari, Italy.
Paola PontrelliNephrology, Dialysis and Transplantation Unit, DETO, University of Bari "Aldo Moro", 70124, Bari, Italy.ORCID 0000-0002-7654-8318
Giuseppe CastellanoNephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Science, University of Foggia, 71122, Foggia, Italy.
Giovanni B PertosaNephrology, Dialysis and Transplantation Unit, DETO, University of Bari "Aldo Moro", 70124, Bari, Italy.
Luigi MacchiaAllergology Unit, DETO, University of Bari "Aldo Moro", 70124, Bari, Italy.
Vito Francesco Di LorenzoUrology Unit, IRCCS Istituto Tumori "Giovanni Paolo II", 70124, Bari, Italy.
Carlo SabbàUrology Unit, IRCCS Istituto Tumori "Giovanni Paolo II", 70124, Bari, Italy.
Anna GalloneDepartment of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari "Aldo Moro", 70124, Bari, Italy.
Loreto GesualdoNephrology, Dialysis and Transplantation Unit, DETO, University of Bari "Aldo Moro", 70124, Bari, Italy.
Fabio SallustioDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124, Bari, Italy.ORCID 0000-0002-5132-6532
University of Bari Aldo Moro · ITIstituto Tumori Bari · ITUniversity of Foggia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adult Renal Stem/Progenitor Cells (ARPCs) have been recently identified in the human kidney and several studies show their active role in kidney repair processes during acute or chronic injury. However, little is known about their immunomodulatory properties and their capacity to regulate specific T cell subpopulations. We co-cultured ARPCs activated by triggering Toll-Like Receptor 2 (TLR2) with human peripheral blood mononuclear cells for 5 days and 15 days and studied their immunomodulatory capacity on T cell subpopulations. We found that activated-ARPCs were able to decrease T cell proliferation but did not affect CD8

Indexed as

Adult Stem CellsBiomarkersCell ProliferationChemokinesHumansImmunomodulationImmunophenotypingKidneyLeukocytes, MononuclearT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsToll-Like Receptor 2BiomarkersChemokinesTLR2 protein, humanToll-Like Receptor 2DN T cellsImmunomodulationrenal diseasesStem CellsTregs

Identifiers

PMID33383950
PMCPMC7795073
OpenAlexW3116430787

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.