ArticleMicroorganisms2020
Probiotic Alternative to Chlorhexidine in Periodontal Therapy: Evaluation of Clinical and Microbiological Parameters.
Article in Microorganisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The efficacy of lactic acid bacteria-based toothpaste on oral health: a systematic review and meta-analysis.Frontiers in oral health · 2025Pooled it
- Probiotics in the non-surgical treatment of periodontitis: a systematic review and network meta-analysis.BMC oral health · 2024Pooled it
- Pooled it
- Probiotic-Containing Nanofiber-Based Dental Floss Suppresses Subgingival Red Complex Periopathogens: A Randomized Double-Blind Crossover Trial.Probiotics and antimicrobial proteins · 2026Trial
- Adjunctive therapea - a promising method in the treatment of periodontal disease.Clinical oral investigations · 2025Trial
- A chewing gum containing ethylenediaminetetraaceticacid (EDTA), methyl sulfonyl methane (MSM) and xylitol works comparable to chlorehexidine mouthrinse.Scientific reports · 2024Trial
- Evaluation of a new mouthwash formulated with Chlorhexidine and Cymenol after a scaling and root planing treatment in grade I and II periodontal patients.Medicina oral, patologia oral y cirugia bucal · 2024Trial
- Trial
- Effects of water flossing on gingival inflammation and supragingival plaque microbiota: a 12-week randomized controlled trial.Clinical oral investigations · 2023Trial
- Pain perception following computer-controlled versus conventional dental anesthesia: randomized controlled trial.BMC oral health · 2022Trial
- Viable and Heat-Killed Probiotic Strains Improve Oral Immunity by Elevating the IgA Concentration in the Oral Mucosa.Current microbiology · 2021Trial
- Mediterranean diet and its relationship with oral pathology.Acta odontologica Scandinavica · 2026Article
- Bridging Guidelines and Oral Healthcare: Development and Initial Validation of a Questionnaire Assessing Early-Career Dentists' Attitudes Toward Periodontal Therapy-A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Exploring the Therapeutic Potential of Diverse Bacterial Strains for Management of Periodontal Diseases.Probiotics and antimicrobial proteins · 2026Review
- Astaxanthin enhances migration, Type I and Type III collagen production, and osteogenic differentiation in periodontal ligament fibroblasts under hyperglycemic conditions.BMC oral health · 2026Article
- In Vivo Evaluation of Lacticaseibacillus reuteri and Lacticaseibacillus rhamnosus Lysates for Oral Wound Healing.Probiotics and antimicrobial proteins · 2026Article
- Review
- Probiotics in Periodontal Diseases: Mechanisms, Evidence Mapping, Limitations, and Future Directions.Cureus · 2025Review
- Association Between Chewing Status and Steatotic Liver Disease in Japanese People Aged ≥50 Years: A Cohort Study.Healthcare (Basel, Switzerland) · 2025Article
- Association between Dietary Live Microbe Intake and Periodontitis in Adults: Evidence from NHANES.Oral health & preventive dentistry · 2025Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontitis consists of a progressive destruction of tooth-supporting tissues. Considering that probiotics are being proposed as a support to the gold standard treatment Scaling-and-Root-Planing (SRP), this study aims to assess two new formulations (toothpaste and chewing-gum). 60 patients were randomly assigned to three domiciliary hygiene treatments: Group 1 (SRP + chlorhexidine-based toothpaste) (control), Group 2 (SRP + probiotics-based toothpaste) and Group 3 (SRP + probiotics-based toothpaste + probiotics-based chewing-gum). At baseline (T
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.