Evidence map›Paper›PMID 33383842›Full record

ArticleMarine drugs2020

Preparation, COX-2 Inhibition and Anticancer Activity of Sclerotiorin Derivatives.

Tao Chen, Yun Huang, Junxian Hong, Xikang Wei, Fang Zeng, Jialin Li, Geting Ye, Jie Yuan, Yuhua Long

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

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  11. Secondary Metabolites withMarine drugs · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Tao ChenSchool of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou 510006, China.
Yun HuangDepartment of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Junxian HongSchool of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou 510006, China.
Xikang WeiSchool of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou 510006, China.
Fang ZengSchool of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou 510006, China.
Jialin LiSchool of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou 510006, China.
Geting YeSchool of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou 510006, China.
Jie YuanDepartment of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Yuhua LongSchool of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou 510006, China.
South China Normal University · CNSouthern Medical University · CNSun Yat-sen University · CN

Funding

Guangdong MEPP Fund GDOE [2019]A21National Natural Science Foundation of China 41876153the Key Project of Natural Science Foundation of Guangdong Province 2016A030311026
6 · The paper itself

Abstract

The latest research has indicated that anti-tumor agents with COX-2 inhibitory activity may benefit their anti-tumor efficiency. A series of sclerotiorin derivatives have been synthesized and screened for their cytotoxic activity against human lung cancer cells A549, breast cancer cells MDA-MB-435 using the MTT method. Among them, compounds

Indexed as

A549 CellsAntineoplastic AgentsBenzopyransCell SurvivalCyclooxygenase 2Cyclooxygenase 2 InhibitorsDose-Response Relationship, DrugHumansInhibitory Concentration 50Molecular Docking SimulationMolecular StructureNeoplasmsStructure-Activity RelationshipAntineoplastic AgentsBenzopyransCyclooxygenase 2Cyclooxygenase 2 InhibitorsPTGS2 protein, humansclerotiorinCOX-2 inhibitioncytotoxic activitymolecular dockingsclerotiorin derivatives

Identifiers

PMID33383842
PMCPMC7823724
OpenAlexW3117618552

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.