SynthesisInternational journal of environmental research and public health2020
Changes in Inflammatory Cytokines in Saliva after Non-Surgical Periodontal Therapy: A Systematic Review and Meta-Analysis.
Synthesis in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- Oral health effects of nicotine pouches in snus users: clinical and immunological findings.Clinical oral investigations · 2026Trial
- Changes in Salivary Interleukin-1 Beta Levels Following a Care Worker-Centered Oral Health Care Program Among Residents of Long-Term Care Facilities.Healthcare (Basel, Switzerland) · 2026Article
- Effects of antiphospholipid antibodies in the severity and outcome of COVID-19.BMC infectious diseases · 2026Article
- Clinical and inflammatory changes following routine scaling and root planing in periodontitis patients with and without diabetes: a prospective observational cohort study.Frontiers in endocrinology · 2026Observational
- The inflammation-pyroptosis axis links local and systemic biomarker profiles to active alveolar bone microstructural deterioration.Frontiers in physiology · 2026Article
- Inflammatory Cytokine Variations After Non-Surgical Periodontal Therapy Across Periodontal Stages and Grades.Dentistry journal · 2025Article
- Salivary and Microbiome Biomarkers in Periodontitis: Advances in Diagnosis and Therapy-A Narrative Review.Medicina (Kaunas, Lithuania) · 2025Review
- Salivary trimethylamine N-oxide: a novel non-invasive marker for periodontal inflammation.Clinical oral investigations · 2025Article
- Results of a Pilot Trial Assessing the Effects of Proper Oral Hygiene and a Probiotic Dietary Supplement on Oral Health in Volunteers with Oral Malodor.Microorganisms · 2024Article
- Article
- Non-Surgical Periodontal Therapy's Influence on Alpha-Synuclein and Inflammatory Marker Levels: A Pilot Study.Journal of clinical medicine · 2024Article
- MMP-8 in Periodontal Sites of Postpartum and without-Any-Pregnancy Women.International journal of environmental research and public health · 2024Article
- Diagnostic Potential of Salivary Interleukin-1International journal of dentistry · 2024Article
- Molecular Basis beyond Interrelated Bone Resorption/Regeneration in Periodontal Diseases: A Concise Review.International journal of molecular sciences · 2023Review
- Potential mechanisms between periodontitis and Alzheimer's disease: a scoping review.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2023Article
- Advances in the prevention and treatment of Alzheimer's disease based on oral bacteria.Frontiers in psychiatry · 2023Review
- Salivary Biomarkers in Periodontitis Post Scaling and Root Planing.Journal of clinical medicine · 2022Article
- What Has Immunology Brought to Periodontal Disease in Recent Years?Archivum immunologiae et therapiae experimentalis · 2022Review
- Assessment of salivary alpha amylase and mucin-4 before and after non-surgical treatment of peri-implant mucositis.International journal of implant dentistry · 2022Article
- Periodontal microorganisms and Alzheimer disease - A causative relationship?Periodontology 2000 · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine the diagnostic value of inflammatory cytokines in periodontal disease, we performed a systematic review of the changes in inflammatory cytokines after non-surgical periodontal therapy and a meta-analysis of the utility of interleukin (IL)-1β and matrix metalloproteinase (MMP)-8 as salivary biomarkers. All available papers published in English until 20 August 2020, were searched in the MEDLINE and EMBASE databases. Population, intervention, comparison, and outcome data were extracted from the selected studies, and the roles of IL-1β and MMP-8 were assessed in a meta-analysis. Eleven studies, including two meta-analyses, were assessed in the systematic review. Biomarkers showing high levels in periodontal disease were salivary IL-1β, IL-4, IL-6, MMP-8, and tissue inhibitor of matrix metalloproteinases (TIMP)-2, and those in the controls were tumor necrosis factor (TNF)-α, IL-10, IL-17, and IL-32. Biomarkers that decreased after scaling and root planning (SRP) and oral hygiene instruction (OHI) in periodontitis patients were IL-1β, MMP-8, MMP-9, prostaglandin E2 (PGE
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.