Evidence map›Paper›PMID 33383820›Full record

ReviewInternational journal of molecular sciences2020

Skeletal Muscle Health and Cognitive Function: A Narrative Review.

Sophia X Sui, Lana J Williams, Kara L Holloway-Kew, Natalie K Hyde, Julie A Pasco

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  8. Temporalis muscle biomarkers from routine brain MRI and risk of dementia in two independent cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sophia X SuiIMPACT-The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Barwon Health, Geelong, VIC 3220, Australia.ORCID 0000-0001-6388-1261
Lana J WilliamsIMPACT-The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Barwon Health, Geelong, VIC 3220, Australia.ORCID 0000-0002-1377-1272
Kara L Holloway-KewIMPACT-The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Barwon Health, Geelong, VIC 3220, Australia.ORCID 0000-0001-5064-2990
Natalie K HydeIMPACT-The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Barwon Health, Geelong, VIC 3220, Australia.ORCID 0000-0002-0693-2904
Julie A PascoIMPACT-The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Barwon Health, Geelong, VIC 3220, Australia.ORCID 0000-0002-8968-4714

Funding

Alfred Deakin Postdoctoral Research Fellowship Kara Holloway-Kewan NHMRC Career Development Fellowship (1064272) and an NHMRC Investigator grant (1174060) Lana WilliamsDeakin Postgraduate Scholarship in conjunction with the Geelong Medical and Hospital Benefits Association Sophia SuiDean's Research Postdoctoral Fellowship (Deakin University). Natalie Hydethe National Health and Medical Research Council (NHMRC) Australia (projects 251638, 628582)-Julie Pasco
6 · The paper itself

Abstract

Sarcopenia is the loss of skeletal muscle mass and function with advancing age. It involves both complex genetic and modifiable risk factors, such as lack of exercise, malnutrition and reduced neurological drive. Cognitive decline refers to diminished or impaired mental and/or intellectual functioning. Contracting skeletal muscle is a major source of neurotrophic factors, including brain-derived neurotrophic factor, which regulate synapses in the brain. Furthermore, skeletal muscle activity has important immune and redox effects that modify brain function and reduce muscle catabolism. The identification of common risk factors and underlying mechanisms for sarcopenia and cognition may allow the development of targeted interventions that slow or reverse sarcopenia and also certain forms of cognitive decline. However, the links between cognition and skeletal muscle have not been elucidated fully. This review provides a critical appraisal of the literature on the relationship between skeletal muscle health and cognition. The literature suggests that sarcopenia and cognitive decline share pathophysiological pathways. Ageing plays a role in both skeletal muscle deterioration and cognitive decline. Furthermore, lifestyle risk factors, such as physical inactivity, poor diet and smoking, are common to both disorders, so their potential role in the muscle-brain relationship warrants investigation.

Indexed as

CognitionAnimalsBiomarkersDisease SusceptibilityHomeostasisHumansLife StyleMuscle, SkeletalMuscle StrengthOrgan SizeOxidative StressPhysical Functional PerformanceRisk FactorsBiomarkerscognitive declinecognitive functioncognitive impairmentdementiainflammationlifestyle risk factorsoxidative stresssarcopeniaskeletal muscle healthvitamin D

Identifiers

PMID33383820
PMCPMC7795998

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.