ArticleCancers2020
Histopathological Chromogranin A-Positivity Is Associated with Right-Sided Colorectal Cancers and Worse Prognosis.
Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Unusual paraneoplastic thrombocytosis in small bowel neuroendocrine tumor responding toJCEM case reports · 2026Article
- Neuroendocrine differentiation and serotonin expression in oesophageal adenocarcinomas after neoadjuvant therapy: correlation with clinicopathological features and outcome.Histopathology · 2025Article
- Holistic exploration ofHeliyon · 2024Article
- Neuroendocrine differentiation: a risk fellow in colorectal cancer.World journal of surgical oncology · 2023Article
- Prediction of hereditary nonpolyposis colorectal cancer using mRNAWorld journal of gastrointestinal pathophysiology · 2021Article
- Prognostic significance of the aberrant expression of neuroendocrine markers in melanomas.Diagnostic pathology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundColorectal cancer (CRC) is known to be affected by paraneoplastic thrombocytosis and chromogranin A-positive neuroendocrine-cell differentiation (CgA
methodsA prospective cohort pilot study of 42 CRC patients and 42 age- and sex-matched controls was carried out. Plasma interleukin-6, thrombopoietin, and serum chromogranin A and -B were measured; furthermore, tumor tissue was immunohistochemically stained for CgA
resultsTwenty-seven and 15 patients were assigned to the chromogranin A-negative (CgA
conclusionsDifferent thrombopoietin levels indicated distinct thrombocytosis types. Within the two CRC groups, serum levels of chromogranins changed in different directions suggesting two well-distinguishable pathophysiologies. Based on these observations we propose a new subtype of CRC, which can be characterized by chromogranin A-positive neuroendocrine-cell differentiation.
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Registered trials
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