ArticleCells2020
Pathologically Decreased CSF Levels of Synaptic Marker NPTX2 in DLB Are Correlated with Levels of Alpha-Synuclein and VGF.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Associations between cerebrospinal fluid markers and cognition in ageing and dementia: A systematic review.The European journal of neuroscience · 2022Pooled it
- Cognitive resilience in preclinical Alzheimer's disease: Higher NPTX2 and VGF levels are associated with reduced cognitive decline.Neurobiology of aging · 2025Article
- VGF AQEE- and GGEE-peptides differentiate between dementia types.Journal of neurology · 2025Article
- Transcriptomic and protein analysis of human cortex reveals genes and pathways linked to NPTX2 disruption in Alzheimer's disease.bioRxiv : the preprint server for biology · 2025Article
- Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration.Nature aging · 2025Article
- Development and validation of a novel Simoa assay for NPTX2 in Alzheimer's disease and Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Evaluation of cerebrospinal fluid levels of VAMP-2 and SNAP-25 in a dementia with Lewy bodies clinical cohort stratified by Alzheimer's pathophysiological biomarkers.Alzheimer's research & therapy · 2025Article
- Addressing inter individual variability in CSF levels of brain derived proteins across neurodegenerative diseases.Scientific reports · 2025Article
- Cerebrospinal fluid biomarker panel for synaptic dysfunction in a broad spectrum of neurodegenerative diseases.Brain : a journal of neurology · 2024Article
- Lysosomal and synaptic dysfunction markers in longitudinal cerebrospinal fluid of de novo Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Biofluid biomarkers for Alzheimer's disease.Frontiers in aging neuroscience · 2024Review
- Serum NFL and tau, but not serum UCHL-1 and GFAP or CSF SNAP-25, NPTX2, or sTREM2, correlate with delirium in a 3-year retrospective analysis.Frontiers in neurology · 2024Article
- How should we be using biomarkers in trials of disease modification in Parkinson's disease?Brain : a journal of neurology · 2023Article
- NPTX2 in Cerebrospinal Fluid Predicts the Progression From Normal Cognition to Mild Cognitive Impairment.Annals of neurology · 2023Article
- Brain-Biomarker Changes in Body Fluids of Patients with Parkinson's Disease.International journal of molecular sciences · 2023Review
- Cerebrospinal fluid biomarker panel of synaptic dysfunction in Alzheimer's disease and other neurodegenerative disorders.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- CSF-Targeted Proteomics Indicate Amyloid-Beta Ratios in Patients with Alzheimer's Dementia Spectrum.International journal of Alzheimer's disease · 2023Article
- Biomarkers of Dementia with Lewy Bodies: Differential Diagnostic with Alzheimer's Disease.International journal of molecular sciences · 2022Review
- Article
- Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration.Journal of neural transmission (Vienna, Austria : 1996) · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 3 institutions in 3 countries.
Walter A BoitenNeurochemistry Department, Clinical Chemistry, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands.ORCID 0000-0001-9060-6222
Inger van SteenovenNeurochemistry Department, Clinical Chemistry, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands.
Mei-Fang XiaoDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-1681-2161
Paul F WorleyDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Barbara NoliNEF-Laboratory, Department of Biomedical Sciences, University of Cagliari, 09042 Monserrato, Italy.
Cristina CoccoNEF-Laboratory, Department of Biomedical Sciences, University of Cagliari, 09042 Monserrato, Italy.
Gian-Luca FerriNEF-Laboratory, Department of Biomedical Sciences, University of Cagliari, 09042 Monserrato, Italy.ORCID 0000-0003-2768-349X
Afina W LemstraDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands.
Charlotte E TeunissenNeurochemistry Department, Clinical Chemistry, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands.ORCID 0000-0002-4061-0837
Amsterdam University Medical Centers · NLUniversity of Cagliari · ITJohns Hopkins University · US
Funding
De novo Synthesis and MemoryR35NS097966 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WORLEY, PAUL F · 2017 to 2024
$4.3MNINDS NIH HHS R35 NS097966
Abstract
PubMed holds no abstract for this paper.
Indexed as
Agedalpha-SynucleinBiomarkersCase-Control StudiesCognitive DysfunctionCohort StudiesC-Reactive ProteinFemaleHumansLewy Body DiseaseMaleMiddle AgedNerve Growth FactorsNerve Tissue ProteinsPentraxinsalpha-SynucleinBiomarkersC-Reactive ProteinNerve Growth FactorsNerve Tissue ProteinsPentraxinsSNCA protein, humanVGF protein, humanAlzheimer’s diseasebiomarkerscerebral spinal fluidcognitive functiondementia with Lewy bodiesneuronal pentraxin 2VGF (non-acronym)visual spatial domainα-synuclein
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.