Evidence map›Paper›PMID 33383158›Full record

ArticleMitochondrion2021

Mitochondrial OPA1 cleavage is reversibly activated by differentiation of H9c2 cardiomyoblasts.

Iraselia Garcia, Fredy Calderon, Patrick De la Torre, Shaynah St Vallier, Cristobal Rodriguez, Divya Agarwala, Megan Keniry, Wendy Innis-Whitehouse, Robert Gilkerson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mitochondrion, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. The Role of Mitochondria in Metabolic Syndrome-Associated Cardiomyopathy.Oxidative medicine and cellular longevity · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Iraselia GarciaDepartment of Biology, The University of Texas Rio Grande Valley, Edinburg, TX, USA; Department of Biology, South Texas College, McAllen, TX, USA.
Fredy CalderonDepartment of Biology, The University of Texas Rio Grande Valley, Edinburg, TX, USA.
Patrick De la TorreDepartment of Biology, The University of Texas Rio Grande Valley, Edinburg, TX, USA.
Shaynah St VallierDepartment of Biology, The University of Texas Rio Grande Valley, Edinburg, TX, USA.
Cristobal RodriguezDepartment of Biology, The University of Texas Rio Grande Valley, Edinburg, TX, USA.
Divya AgarwalaDepartment of Biology, The University of Texas Rio Grande Valley, Edinburg, TX, USA.
Megan KeniryDepartment of Biology, The University of Texas Rio Grande Valley, Edinburg, TX, USA.
Wendy Innis-WhitehouseBiomedical Sciences, The University of Texas Rio Grande Valley, Edinburg, TX, USA.
Robert GilkersonDepartment of Biology, The University of Texas Rio Grande Valley, Edinburg, TX, USA; Clinical Laboratory Sciences, The University of Texas Rio Grande Valley, Edinburg, TX, USA. Electronic address: robert.gilkerson@utrgv.edu.
The University of Texas Rio Grande Valley · USSouth Texas College · US

Funding

Interaction of mitochondrial fusion and transmembrane potential in diabetic cardiovascular damageSC3GM116669 · NIGMS · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI GILKERSON, ROBERT W · 2016 to 2023
$872k
Investigating the Roles and Regulation of FOXO Transcription Factors in GBM and basal breast cancerSC3GM132053 · NIGMS · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI KENIRY, MEGAN E · 2019 to 2022
$436k
NIGMS NIH HHS SC3 GM116669NIGMS NIH HHS SC3 GM132053
6 · The paper itself

Abstract

Optic atrophy-1 (OPA1) is a dynamin-like GTPase localized to the mitochondrial inner membrane, playing key roles in inner membrane fusion and cristae maintenance. OPA1 is regulated by the mitochondrial transmembrane potential (Δψ

Indexed as

AnimalsApoptosisCell DifferentiationCell Line, TumorGTP PhosphohydrolasesHumansMembrane PotentialsMetalloendopeptidasesMiceMitochondria, HeartMitochondrial MembranesMyocytes, CardiacRatsTretinoinGTP PhosphohydrolasesMetalloendopeptidasesOpa1 protein, ratTretinoinCardiacCultured cellDifferentiationMitochondriaOMA1OPA1

Identifiers

PMID33383158
PMCPMC7904612
OpenAlexW3114034460

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.