Evidence map›Paper›PMID 33382960›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2021

Mechanisms of bone blood flow regulation in humans.

Adina E Draghici, J Andrew Taylor

Open access · greenAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Association of cardiorespiratory fitness with HR-pQCT bone parameters in older adults: the Study of Muscle, Mobility and Aging (SOMMA).Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Article
  4. The role of sympathetic control in bone vasculature: insights from spinal cord injury.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Nitric oxide-mediated vasodilation in human bone.Microcirculation (New York, N.Y. : 1994) · 2024
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Adina E DraghiciDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0003-2541-2661
J Andrew TaylorDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts.
Harvard University · US

Funding

Exploration of blood flow regulation to bone in humansR21AR074054 · NIAMS · SPAULDING REHABILITATION HOSPITAL · PI TAYLOR, J ANDREW · 2019 to 2020
$407k
NIAMS NIH HHS 1R21AR074054NIAMS NIH HHS R21 AR074054
6 · The paper itself

Abstract

Bone is a highly vascularized tissue. However, despite the importance of appropriate circulation for bone health, regulation of bone blood flow remains poorly understood. Invasive animal studies suggest that sympathetic activity plays an important role in bone flow control. However, it remains unknown if bone vasculature evidences robust vasoconstriction in response to sympathoexcitatory stimuli. Here, we characterized bone blood flow in young healthy individuals [

Indexed as

Hand StrengthSympathetic Nervous SystemBlood PressureFemaleHemodynamicsHumansVasoconstrictionbone blood flowcold pressor testisometric handgripnear infrared spectroscopysympathetic vasosconstriction

Identifiers

PMID33382960
PMCPMC7988789
OpenAlexW3116871564

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.