ArticleThe Journal of clinical endocrinology and metabolism2021
Reduced Muscle Strength Is Associated With Insulin Resistance in Type 2 Diabetes Patients With Osteoarthritis.
Article in The Journal of clinical endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05878587 (Effects of Burger Allen Exercises on Pain, Range of Motion, and Disability in Knee Osteoarthritis With Type II Diabetes), which is not on this map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Burger Allen Exercises on Pain, Range of Motion, and Disability in Knee Osteoarthritis With Type II Diabetes
Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Relationship between triglyceride-glucose index and muscle strength in middle-aged and older Chinese adults without chronic diseases: a nationwide longitudinal cohort study.Scientific reports · 2026Article
- Association of the combined atherosclerosis index of plasma and frailty index with arthritis in middle-aged and older adults: a cohort study.Scientific reports · 2026Article
- Association between the sarcopenia index and osteoarthritis: a cross-sectional and longitudinal study.European journal of medical research · 2026Article
- Linking diabetes to worsening knee osteoarthritis symptoms and disability: evidence from the osteoarthritis initiative.Frontiers in medicine · 2026Article
- Type 2 Diabetes Mellitus Modifies the Association Between Exercise Therapy and Injury Risk and Long-Term Outcomes in Patients with Knee Osteoarthritis: A Retrospective Cohort Study.Journal of pain research · 2026Article
- First metatarsophalangeal joint synovial hypertrophy associated with vitamin D status in type 2 diabetes mellitus: An ultrasound-graded study.World journal of diabetes · 2025Article
- More comprehensive relationship between eGDR and sarcopenia in China: a nationwide cohort study with national representation.Diabetology & metabolic syndrome · 2025Article
- Combined knee osteoarthritis and diabetes is associated with reduced muscle strength, physical inactivity, and poorer quality of life.Journal of rehabilitation medicine · 2024Article
- Association of the visceral fat metabolic score with osteoarthritis risk: a cross-sectional study from NHANES 2009-2018.BMC public health · 2024Article
- Diabetes and Functional Impairment in Osteoarthritis: Investigating Correlations, Associations, and Progression.Cureus · 2024Article
- Obesity, Metabolic Syndrome, and Osteoarthritis Require Integrative Understanding and Management.Biomedicines · 2024Review
- Association between higher triglyceride glucose index and increased risk of osteoarthritis: data from NHANES 2015-2020.BMC public health · 2024Article
- Osteoarthritis and Diabetes: Where Are We and Where Should We Go?Diagnostics (Basel, Switzerland) · 2023Review
- [Research progress on the correlation between sarcopenia and osteoarthritis].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2022Review
- Review
- The Intriguing Intersection of Type 2 Diabetes, Obesity-Related Insulin Resistance, and Osteoarthritis.The Journal of clinical endocrinology and metabolism · 2021Article
Corrections and comments
- Commented on by
Authors and funding
18 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextType 2 diabetes is associated with a greater risk for musculoskeletal disorders, yet its impact on joint function remains unclear.
objectiveWe hypothesized that patients with type 2 diabetes and osteoarthritis would exhibit musculoskeletal impairment, which would associate with insulin resistance and distinct microRNA profiles.
methodsParticipants of the German Diabetes Study with type 2 diabetes (T2D, n = 39) or normal glucose tolerance (CON, n = 27), both with (+OA) or without osteoarthritis (-OA) underwent intravenous glucose tolerance and hyperinsulinemic-euglycemic clamp tests. Musculoskeletal function was assessed by isometric knee extension strength (KES), grip strength, range of motion (ROM), and balance skills, while neural function was measured by nerve conductance velocity (NCV). Arthritis-related symptoms were quantified using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire, serum arthritis-related microRNA using quantitative polymerase chain reaction.
resultsInsulin sensitivity was lower in T2D+OA vs T2D-OA (4.4 ± 2.0 vs 5.7 ± 3.0 mg* kg-1*min-1) and in CON+OA vs CON-OA (8.1 ± 2.0 vs 12.0 ± 2.6 mg*kg-1,*min-1, both P < .05). In T2D+OA, KES and ROM were 60% and 22% lower than in CON+OA, respectively (both P < .05). Insulin sensitivity correlated positively with KES (r = 0.41, P < .05) among T2D, and negatively with symptom severity in CON and T2D (r = -0.60 and r = -0.46, respectively, P < .05). CON+OA and T2D+OA had inferior balance skills than CON-OA, whereas NCV was comparable in T2D+OA and T2D-OA. Expression of arthritis-related microRNAs was upregulated in T2D compared to CON, but downregulated in CON+OA compared to CON-OA (P < .05), and did not differ between T2D+OA and T2D-OA.
conclusionMusculoskeletal impairment and osteoarthritis-related symptoms are associated with insulin resistance. Type 2 diabetes can mask changes in arthritis-related microRNA profiles.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.