ArticlePloS one2020
Association between prediagnosis depression and mortality among postmenopausal women with colorectal cancer.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
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The trial behind it
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Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 10 citations in OpenAlex.
- Depression increases cancer mortality by 23-83%: a meta-analysis of 65 studies across five major cancer types.GeroScience · 2026Pooled it
- Colorectal cancer mortality in persons with severe mental illness: a scoping review with meta-analyses of observational studies.Acta oncologica (Stockholm, Sweden) · 2025Pooled it
- Prognostic value of depression and anxiety on colorectal cancer-related mortality: a systematic review and meta-analysis based on univariate and multivariate data.International journal of colorectal disease · 2024Pooled it
- Psychiatric disorders associated with increased risk of colorectal cancer in the UK biobank cohort.Scientific reports · 2026Article
- Incidence of new-onset depression after colorectal cancer diagnosis and associated mortality: a population-based cohort study.BMJ oncology · 2026Article
- Tanshinone IIA induces ferroptosis in colorectal cancer cells through the suppression of SLC7A11 expression via the PI3K/AKT/mTOR pathway.European journal of medical research · 2025Article
- Mental illness and non-metastatic colorectal cancer treatment and survival, a nationwide study of almost 70,000 patients.Acta oncologica (Stockholm, Sweden) · 2025Article
- Association Between Depression and Lung Cancer Risk Among Postmenopausal Women.Cancer medicine · 2025Article
- Mediating role of accelerated aging in the association between depression and mortality risk: findings from NHANES.Aging clinical and experimental research · 2024Article
- Article
- Depressive symptoms and antidepressant use in relation to white blood cell count among postmenopausal women from the Women's Health Initiative.Translational psychiatry · 2024Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThere are no epidemiologic data on the relation of depression before colorectal cancer diagnosis to colorectal cancer mortality among women with colorectal cancer, especially those who are postmenopausal. Our aim was to fill this research gap.
methodsWe analyzed data from a large prospective cohort in the US, the Women's Health Initiative (WHI). The study included 2,396 women with incident colorectal cancer, assessed for depressive symptoms and antidepressant use before cancer diagnosis at baseline (screening visit in the WHI study) during 1993-1998. Participants were followed up from cancer diagnosis till 2018. We used Cox proportional hazards regression to estimate adjusted hazard ratios (HRs) between depression (depressive symptoms or antidepressant use) at baseline, and all-cause mortality and colorectal cancer-specific mortality.
resultsAmong women with colorectal cancer, there was no association between baseline depression and all-cause mortality or colorectal cancer-specific mortality after adjusting for age or multiple covariates.
conclusionAmong women with colorectal cancer, there was no statistically significant association between depression before colorectal cancer diagnosis and all-cause mortality or colorectal cancer-specific mortality. Further studies are warranted to assess depressive symptoms and antidepressant use, measured at multiple points from baseline to diagnosis, and their interactions with specific types of colorectal cancer treatment on the risk of death from colorectal cancer.
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Registered trials
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