Evidence map›Paper›PMID 33382597›Full record

ArticleBiochemistry2021

Structure of a Stable Interstrand DNA Cross-Link Involving a β-

Andrew H Kellum, David Y Qiu, Markus W Voehler, William Martin, Kent S Gates, Michael P Stone

Abstract read
In one paragraph

Article in Biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Stable Interstrand Cross-Links Generated from the Repair of 1,Journal of the American Chemical Society · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrew H KellumDepartment of Chemistry, Vanderbilt University Center for Structural Biology, and the Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37235, United States.
David Y QiuDepartment of Chemistry, Vanderbilt University Center for Structural Biology, and the Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37235, United States.
Markus W VoehlerDepartment of Chemistry, Vanderbilt University Center for Structural Biology, and the Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37235, United States.
William MartinDepartment of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, United States.
Kent S GatesDepartments of Chemistry and Biochemistry, University of Missouri, Columbia, Missouri 65221, United States.ORCID 0000-0002-4218-7411
Michael P StoneDepartment of Chemistry, Vanderbilt University Center for Structural Biology, and the Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0002-0922-0216

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
Structural Biology Facility CoreP30ES000267 · NIEHS · VANDERBILT UNIVERSITY · PI GUENGERICH, F PETER · 1985 to 2014
$20.3M
Synthetic Approaches to Carcinogen-Linked OligonucleotidesP01CA160032 · NCI · VANDERBILT UNIVERSITY · PI STONE, MICHAEL P · 2012 to 2022
$14.0M
DNA Adduct-Induced MutagenesisR01CA055678 · NCI · VANDERBILT UNIVERSITY · PI STONE, MICHAEL P · 1992 to 2016
$4.0M
DNA Adduct-Induced MutagenesisR01ES029357 · NIEHS · VANDERBILT UNIVERSITY · PI STONE, MICHAEL P · 2018 to 2022
$2.6M
Console upgrades for biological NMR spectrometersS10RR025677 · NCRR · VANDERBILT UNIVERSITY · PI SANDERS, CHARLES R · 2009 to 2009
$460k
ARRA NIH HHSNCI NIH HHS P01 CA160032NCI NIH HHS P30 CA068485NCI NIH HHS R01 CA055678NCRR NIH HHS S10 RR025677NIEHS NIH HHS P30 ES000267NIEHS NIH HHS R01 ES029357
6 · The paper itself

Abstract

Abasic (AP) sites are one of the most common forms of DNA damage. The deoxyribose ring of AP sites undergoes anomerization between α and β configurations, via an electrophilic aldehyde intermediate. In sequences where an adenine residue is located on the opposing strand and offset 1 nt to the 3' side of the AP site, the nucleophilic

Indexed as

DNA DamageAdenineAldehydesCross-Linking ReagentsDNADNA RepairHumansNucleic Acid ConformationAdenineAldehydesCross-Linking ReagentsDNA

Identifiers

PMID33382597
PMCPMC7952047

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.