Evidence map›Paper›PMID 33382539›Full record

ArticleClinical and experimental dental research2021

Implant functionalization with mesoporous silica: A promising antibacterial strategy, but does such an implant osseointegrate?

Katleen Vandamme, Karin Thevissen, Marcelo F Mesquita, Ruxandra-Gabriella Coropciuc, Jimoh Agbaje, Patrick Thevissen, Wander José da Silva, Jozef Vleugels, Kaat De Cremer, Evelien Gerits and 4 more

Open access · goldAbstract read
In one paragraph

Article in Clinical and experimental dental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. The Japanese dental science review · 2026
    Review
  2. Autonomous Implants.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Katleen VandammeDepartment of Oral Health Sciences & Restorative Dentistry, Biomaterials-BIOMAT, KU Leuven & University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0002-5766-2254
Karin ThevissenCentre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium.
Marcelo F MesquitaDepartment of Oral Health Sciences & Restorative Dentistry, Biomaterials-BIOMAT, KU Leuven & University Hospitals Leuven, Leuven, Belgium.
Ruxandra-Gabriella CoropciucOral and Maxillo-facial Surgery, Imaging & Pathology (OMFS-IMPATH), Department of Oral Health Sciences & Department of Imaging and Pathology, KU Leuven & University Hospitals Leuven, Leuven, Belgium.
Jimoh AgbajeOral and Maxillo-facial Surgery, Imaging & Pathology (OMFS-IMPATH), Department of Oral Health Sciences & Department of Imaging and Pathology, KU Leuven & University Hospitals Leuven, Leuven, Belgium.
Patrick ThevissenForensic Odontology, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.
Wander José da SilvaDepartment of Oral Health Sciences & Restorative Dentistry, Biomaterials-BIOMAT, KU Leuven & University Hospitals Leuven, Leuven, Belgium.
Jozef VleugelsDepartment of Materials Engineering, KU Leuven, Leuven, Belgium.
Kaat De CremerCentre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium.
Evelien GeritsCentre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium.
Johan A MartensCentre of Surface Chemistry and Catalysis, KU Leuven, Leuven, Belgium.
Jan MichielsCentre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium.
Bruno P A CammueCentre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium.
Annabel BraemDepartment of Materials Engineering, KU Leuven, Leuven, Belgium.
KU Leuven · BEVlaams Instituut voor Biotechnologie · BEUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

FAPESP 2015/19327-5Industrial Research Fund IOFm/05/022Industrial Research Fund of KU Leuven IOF/KP/11/007Internal Funds KU Leuven STG/17/024
6 · The paper itself

Abstract

objectivesNew strategies for implant surface functionalization in the prevention of peri-implantitis while not compromising osseointegration are currently explored. The aim of this in vivo study was to assess the osseointegration of a titanium-silica composite implant, previously shown to enable controlled release of therapeutic concentrations of chlorhexidine, in the Göttingen mini-pig oral model. MATERIAL AND

methodsThree implant groups were designed: macroporous titanium implants (Ti-Porous); macroporous titanium implants infiltrated with mesoporous silica (Ti-Porous + SiO

resultsBone-to-implant contact and peri-implant bone volume for Ti-Porous versus Ti-Porous + SiO

conclusionsNext-generation implants made of macroporous Ti infiltrated with mesoporous SiO

Indexed as

Prostheses and ImplantsAnimalsAnti-Bacterial AgentsDental ImplantsPeri-ImplantitisSilicon DioxideSurface PropertiesSwineSwine, MiniatureTitaniumAnti-Bacterial AgentsDental ImplantsSilicon DioxideTitaniumminiatureosseointegrationsilicon dioxideswinetitanium

Identifiers

PMID33382539
PMCPMC8404489
OpenAlexW3114533527

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.