Evidence map›Paper›PMID 33382482›Full record

SynthesisClinical cardiology2021

Prevalence and impact of cardiac injury on COVID-19: A systematic review and meta-analysis.

Linghua Fu, Xiao Liu, Yuhao Su, Jianyong Ma, Kui Hong

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 4 pooled it
0.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Health-Related Quality of Life of Moroccan COVID-19 Survivors: A Case-Control Study.International journal of environmental research and public health · 2022
    Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Recent Progresses in Electrochemical DNA Biosensors for SARS-CoV-2 Detection.Frontiers in bioengineering and biotechnology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Linghua FuCardiology Department, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Xiao LiuCardiology Department, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.ORCID https://orcid.org/0000-0002-5570-289X
Yuhao SuCardiology Department, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Jianyong MaCardiology Department, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Kui HongCardiology Department, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.ORCID https://orcid.org/0000-0002-0875-0557
Nanchang University · CN

Funding

National Natural Science Foundation of China 81530013Postgraduate Innovation Foundation of Nanchang University CX-2017198Scientific and Technical Innovation Group of Jiangxi Province 20181BCB24012
6 · The paper itself

Abstract

backgroundThe exact prevalence and impact of cardiac injury in hospitalized patients with coronavirus disease 2019 (COVID-19) is still controversial. Hence, we aim to investigate prevalence of cardiac injury and its impact on the outcomes in patients with COVID-19. HYPOTHESIS: Cardiac injury is common and associated with higher risk of death.

methodsWe searched the Cochrane Library, PubMed, MedRxiv, and EMBASE databases from December 2019 to July 15, 2020 for studies that evaluated the prevalence and impact of cardiac injury on COVID-19. This study has been registered with PROSPERO (International prospective register of systematic reviews)-registration number-CRD-42020186120.

resultsTwenty-one studies including 6297 participants were identified. The proportions of cardiac injury were 22%, 28% among hospitalized patients with COVID-19 or severe COVID-19 patients, respectively. The incidences of cardiac injury in advance age (>60 years) (30%) was about two-fold than young patients (<60 years) (15%) with COVID-19. Severe cases (42%) have seven-fold prevalence cardiac injury than in their non- severe counterparts (6%). Furthermore, cardiac injury is associated with an increased risk of all-cause mortality in patients with COVID-19 (OR 10.11, 95% CI 4.49-22.77). In patients with severe COVID-19, cardiac injury is associated with an increased risk of all-cause mortality (OR: 16.79, 95% CI: 5.52-51.02).

conclusionsThis was the first meta-analysis exploring the prevalence and impact of cardiac injury on COVID-19. Cardiac injury is common in hospitalized patients and advanced age and severe COVID-19 patients prone to experience more risk of cardiac injury. Furthermore, cardiac injury is associated with increased risk of all-cause mortality.

Indexed as

Cardiovascular DiseasesCOVID-19HumansPrevalenceSARS-CoV-2cardiac injurycoronavirus disease 2019deathintensive care unit

Identifiers

PMID33382482
PMCPMC7852167
OpenAlexW3114703458

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.