Evidence map›Paper›PMID 33382363›Full record

ArticleGut microbes

Immunostimulatory membrane proteins potentiate

Matthew G Varga, Cecily R Wood, Julia Butt, Mackenzie E Ryan, Wei-Cheng You, Kaifeng Pan, Tim Waterboer, Meira Epplein, Carrie L Shaffer

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Characterization ofFrontiers in microbiology · 2026
    Article
  2. Species-specific components of theInfection and immunity · 2025
    Article
  3. Article
  4. High-Salt Diet ExacerbatesJournal of personalized medicine · 2023
    Review
  5. A Predictive Model of Noncardia Gastric Adenocarcinoma Risk Using Antibody Response to Helicobacter pylori Proteins and Pepsinogen.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022
    Article
  6. TheGut microbes
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Matthew G VargaDepartment of Epidemiology, Lineberger Comprehensive Cancer Center and Gillings School of Global Public Health, University of North Carolina , Chapel Hill, NC, USA.
Cecily R WoodDepartment of Veterinary Science, University of Kentucky , Lexington, KY, USA.
Julia ButtInfections and Cancer Epidemiology, German Cancer Research Center , Heidelberg, Germany.
Mackenzie E RyanDepartment of Microbiology, Immunology, and Molecular Genetics, University of Kentucky , Lexington, KY, USA.
Wei-Cheng YouDepartment of Cancer Epidemiology, Peking University Cancer Hospital and Institute , Beijing, China.
Kaifeng PanDepartment of Cancer Epidemiology, Peking University Cancer Hospital and Institute , Beijing, China.
Tim WaterboerInfections and Cancer Epidemiology, German Cancer Research Center , Heidelberg, Germany.
Meira EppleinDepartment of Population Health Sciences and Duke Cancer Institute, Cancer Control and Population Sciences Program, Duke University , Durham, NC, USA.
Carrie L ShafferDepartment of Veterinary Science, University of Kentucky , Lexington, KY, USA.ORCID 0000-0002-7457-7422
University of Kentucky · USGerman Cancer Research Center · DEPeking University · CNDuke University · USUniversity of North Carolina at Chapel Hill · US

Funding

Understanding the role of anti-apolipoprotein A-I antibodies in atherosclerotic cardiovascular diseaseP20GM130456 · NIGMS · UNIVERSITY OF KENTUCKY · PI M. Ashfaqul Alam · 2020 to 2026
$18.7M
Protein CoreP30GM110787 · NIGMS · UNIVERSITY OF KENTUCKY · PI WHITEHEART, SIDNEY WALDO · 2014 to 2018
$5.7M
Cancer Control Education ProgramT32CA057726 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa B Gilkey, Melissa A. Troester · 2017 to 2026
$3.7M
Helicobacter pylori blood biomarker for gastric cancer risk in East AsiaR01CA174853 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI EPPLEIN, MEIRA · 2013 to 2016
$2.3M
NCI NIH HHS R01 CA174853NCI NIH HHS T32 CA057726NIGMS NIH HHS P20 GM130456NIGMS NIH HHS P30 GM110787
6 · The paper itself

Abstract

Infection with

Indexed as

Antibodies, BacterialAntigens, BacterialBacterial Outer Membrane ProteinsBacterial ProteinsCell LineCytokinesFemaleGastric MucosaGene Expression Regulation, BacterialHelicobacter InfectionsHelicobacter pyloriHumansMaleMiddle AgedMutationPepsinogen AAntibodies, BacterialAntigens, BacterialBacterial Outer Membrane ProteinsBacterial ProteinscagA protein, Helicobacter pyloriCytokinesPepsinogen APepsinogen Cbacterial pathogenesisCagAepidemiologygastric cancerHelicobacter pylori

Identifiers

PMID33382363
PMCPMC7781638
OpenAlexW3115974521

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.