ArticleJournal of magnetic resonance imaging : JMRI2021
Estimation of fractional myocardial blood volume and water exchange using ferumoxytol-enhanced magnetic resonance imaging.
Article in Journal of magnetic resonance imaging : JMRI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Ferumoxytol-Enhanced Myocardial T1 Tracking Using a Hybrid 2D/3D Steady-State MRI Sequence Captures Cyclic Intramyocardial Blood Volume Dynamics.NMR in biomedicine · 2026Article
- Decontrasted Image Registration Improves Quantification of Extracellular Volume and Fractional Myocardial Blood Volume.NMR in biomedicine · 2025Article
- Multiscale Coronary Arterial Network Generation and Hemodynamics Using Patient-Specific Fractional Myocardial Blood Volume.Bioengineering (Basel, Switzerland) · 2025Article
- Ferumoxytol-enhanced cardiovascular magnetic resonance imaging: applications and technical advances.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025Review
- Intravenous and oral whole body ketone dosimetry, biodistribution, metabolite correction and kinetics studied by (R)-[1-EJNMMI radiopharmacy and chemistry · 2023Article
- Fractional myocardial blood volume by ferumoxytol-enhanced MRI: Estimation of ischemic burden.Magnetic resonance in medicine · 2023Article
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7 authors.
Funding
Abstract
Fractional myocardial blood volume (fMBV) estimated using ferumoxytol-enhanced magnetic resonance imaging (MRI) (FE-MRI) has the potential to capture a hemodynamic response to myocardial hypoperfusion during contrast steady state without reliance on gadolinium chelates. Ferumoxytol has a long intravascular half-life and its use for steady-state MRI is off-label. The aim of this prospective study was to optimize and evaluate a two-compartment model for estimation of fMBV based on FE-MRI. Nine healthy swine and one swine with artificially induced single-vessel coronary stenosis underwent MRI on a 3.0 T clinical magnet. Myocardial longitudinal spin-lattice relaxation rate (R1) was measured using the 5(3)3(3)3 modified Look-Locker inversion recovery (MOLLI) sequence before and at contrast steady state following seven ferumoxytol infusions (0.125-4.0 mg/kg). fMBV and water exchange were estimated using a two-compartment model. Model-fitted fMBV was compared to simple fast-exchange fMBV approximation and percent change in pre- and postferumoxytol R1. Dose undersampling schemes were investigated to reduce acquisition duration. Variation in fMBV was assessed using one-way analysis of variance. Fast-exchange fMBV and ferumoxytol dose undersampling were evaluated using Bland-Altman analysis. Healthy normal swine showed a mean mid-ventricular fMBV of 7.2 ± 1.4% and water exchange rate of 11.3 ± 5.1 s
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