Evidence map›Paper›PMID 33382161›Full record

ArticleMolecular ecology2021

Gene family amplification facilitates adaptation in freshwater unionid bivalve Megalonaias nervosa.

Rebekah L Rogers, Stephanie L Grizzard, James E Titus-McQuillan, Katherine Bockrath, Sagar Patel, John P Wares, Jeffrey T Garner, Cathy C Moore

Open access · greenAbstract read
In one paragraph

Article in Molecular ecology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
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  7. Comparative Genomic Analysis of Two Monokaryons ofJournal of fungi (Basel, Switzerland) · 2025
    Article
  8. Article
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  11. The First High-Quality Genome Assembly of Freshwater Pearl MusselInternational journal of molecular sciences · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Rebekah L RogersDepartment of Bioinformatics and Genomics, University of North Carolina, Charlotte, NC, USA.ORCID 0000-0003-4678-4464
Stephanie L GrizzardDepartment of Bioinformatics and Genomics, University of North Carolina, Charlotte, NC, USA.
James E Titus-McQuillanDepartment of Bioinformatics and Genomics, University of North Carolina, Charlotte, NC, USA.
Katherine BockrathDepartment of Genetics, University of Georgia, Athens, GA, USA.ORCID 0000-0002-5406-9308
Sagar PatelDepartment of Bioinformatics and Genomics, University of North Carolina, Charlotte, NC, USA.
John P WaresDepartment of Genetics, University of Georgia, Athens, GA, USA.
Jeffrey T GarnerDivision of Wildlife and Freshwater Fisheries, Alabama Department of Conservation and Natural Resources, Florence, AL, USA.
Cathy C MooreDepartment of Bioinformatics and Genomics, University of North Carolina, Charlotte, NC, USA.
University of North Carolina at Charlotte · USAlabama Department of Conservation and Natural Resources · USUnited States Fish and Wildlife Service · USUniversity of Georgia · US

Funding

New Genes and AdaptionR35GM133376 · NIGMS · UNIVERSITY OF NORTH CAROLINA CHARLOTTE · PI Rebekah Lee Rogers · 2019 to 2026
$2.4M
NIGMS NIH HHS R35 GM133376
6 · The paper itself

Abstract

Freshwater unionid bivalves currently face severe anthropogenic challenges. Over 70% of species in the United States are threatened, endangered or extinct due to pollution, damming of waterways and overfishing. These species are notable for their unusual life history strategy, parasite-host co-evolution and biparental mitochondrial inheritance. Among this clade, the washboard mussel Megalonaias nervosa is one species that remains prevalent across the Southeastern United States, with robust population sizes. We have created a reference genome for M. nervosa to determine how genome content has evolved in the face of these widespread environmental challenges. We observe dynamic changes in genome content, with a burst of recent transposable element proliferation causing a 382 Mb expansion in genome content. Birth-death models suggest rapid expansions among gene families, with a mutation rate of 1.16 × 10

Indexed as

Adaptation, PhysiologicalMultigene FamilyUnionidaeAnimalsConservation of Natural ResourcesFisheriesFresh WaterSoutheastern United StatesCytochrome P450evolutionary genomicsgene family expansionM. nervosapopulation genomicsreverse ecological geneticstransposable element evolutionUnionidae

Identifiers

PMID33382161
PMCPMC12066025
OpenAlexW3046544848

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.