ReviewJournal of orthopaedic research : official publication of the Orthopaedic Research Society2021
Masquelet's induced membrane technique: Review of current concepts and future directions.
Review in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
107 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Induced membrane spontaneous osteogenesis leading to tibiofibular fusion: a study of case series and literature review.BMC musculoskeletal disorders · 2026Pooled it
- Masquelet's induced membrane technique in the upper limb: a systematic review of the current outcomes.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2025Pooled it
- Ilizarov method combined with accordion technique for treating long bone defects in the lower limbs: a systematic review.Journal of orthopaedic surgery and research · 2024Pooled it
- Antibiotic bone cement accelerates diabetic foot wound healing: Elucidating the role of ROCK1 protein expression.International wound journal · 2024Trial
- [A prospective randomized controlled study of antibiotic bone cement in the treatment of diabetic foot ulcer].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023Trial
- A High-Energy Military Femoral Fracture With Multidrug-Resistant Infection: A Case Report.The American journal of case reports · 2026Article
- Custom Antibiotic-Coated Intramedullary Nails for Infected Tibial and Femoral Nonunions: Retrospective Cohort Study and Surgical Technique.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026Article
- [Expert consensus on the application of bone cement in the treatment of diabetic wounds (2026 edition)].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Article
- The road to the Pearl-String Technique: lessons learned from early IMT modifications using RIA autograft and cancellous allograft granules.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Cerclage Wire as an Affordable Alternative for Internal Fixation in Murine Critical Sized Defect Models.bioRxiv : the preprint server for biology · 2026Article
- Purine metabolism enhances neovascularization of type H vessels in the induced membrane technique.JCI insight · 2026Article
- Tissue Engineering for Massive Bone Defects: The Volumetric Scaling Problem and Strategies to Solve It.Bioengineering (Basel, Switzerland) · 2026Review
- Foundations for the Successful Establishment of a Multidisciplinary Orthoplastic Surgery Team.Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V... · 2026Review
- Application of axial load-share ratio testing technology in the bone transport treatment of large segmental tibial bone defects.BMC musculoskeletal disorders · 2026Article
- Naringin targets TGF-β1-mediated angiogenesis to enhance the osteogenic effect of induced membrane.Bone & joint research · 2026Article
- Surgically Treated Non-Unions and Fractures of the Femur and Tibia in Adults: A Nationwide Analysis of 888,442 Cases from the German InEK Database.Journal of epidemiology and global health · 2026Article
- [Mechanism of actions and reflections of Masquelet induced membrane technique in diabetic wound].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Review
- Dose-dependent effects of estrogen-enriched bone cement on membrane quality in the Masquelet technique: experimental rat model.Acta orthopaedica et traumatologica turcica · 2026Article
- Patient-Specific Lattice Implants for Segmental Femoral and Tibial Reconstruction (Part 2): CT-Based Personalization, Design Workflows and Validation-A Review.Biomimetics (Basel, Switzerland) · 2026Review
- The masquelet technique for severe open fractures: current insights.Journal of orthopaedic surgery and research · 2026Review
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Masquelet's induced membrane technique (MIMT) is a relatively new, two-stage surgical procedure to reconstruct segmental bone defects. First performed by Dr. Masquelet in the mid-1980s, MIMT has shown great promise to revolutionize critical-sized bone defect repair and has several advantages over its alternative, distraction osteogenesis (DO). Also, its success in extremely challenging cases (defects > 15 cm) suggests that its study could lead to discovery of novel biological mechanisms that might be at play during segmental defect healing and fracture non-union. MIMT's advantages over DO have led to a world-wide increase in MIMT procedures over the past decades. However, MIMT often needs to be repeated and so the average initial success rate in adults lags significantly behind that of DO (86% vs 95%, respectively). The autologous foreign-body membrane created during the first stage by the immune system's response to a polymethyl methacrylate bone cement spacer is critical to supporting the morselized bone graft implanted in the second stage. However, the biological and/or physical mechanisms by which the membrane supports graft to bone union are unclear. This lack of knowledge makes refining MIMT and improving the success rates through technique improvements and patient selection a significant challenge and hinders wider adoption. In this review, current knowledge from basic, translational, and clinical studies is summarized. The dynamics of both stages under normal conditions as well as with drug or material perturbations is discussed along with perspectives on high-priority future research directions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.