Evidence map›Paper›PMID 33382078›Full record

ArticleHistology and histopathology2020

Absence of lymphatic vessels in non-functioning bleb capsules of glaucoma drainage devices.

Robert Siggel, Falk Schroedl, Thomas Dietlein, Konrad R Koch, Christian Platzl, Alexandra Kaser-Eichberger, Claus Cursiefen, Ludwig M Heindl

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Article in Histology and histopathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Robert Siggel *Department of Ophthalmology, University of Cologne, Cologne, Germany.
Falk Schroedl *Institute of Anatomy and Cell Biology, Paracelsus Medical University, Salzburg, Austria.
Thomas DietleinDepartment of Ophthalmology, University of Cologne, Cologne, Germany.
Konrad R KochDepartment of Ophthalmology, University of Cologne, Cologne, Germany.
Christian PlatzlInstitute of Anatomy and Cell Biology, Paracelsus Medical University, Salzburg, Austria.
Alexandra Kaser-EichbergerInstitute of Anatomy and Cell Biology, Paracelsus Medical University, Salzburg, Austria.
Claus CursiefenDepartment of Ophthalmology, University of Cologne, Cologne, Germany.
Ludwig M HeindlDepartment of Ophthalmology, University of Cologne, Cologne, Germany.

Funding

Adele-Rabensteiner- Stiftung -CMMK Cologne -EU ARREST BLINDNESS -EU COST BM1302 -EU STRONG -FOR2240 -PMU-FFF E-15/22/113-COSPMU-FFF R-15/02/067-KAS
6 · The paper itself

Abstract

purposeTo evaluate the presence and appearance of blood and lymphatic vessels in non-functioning bleb capsules of glaucoma drainage devices (GDD). MATERIALS AND

methodsNon-functioning (n=14) GDD-bleb capsules of 12 patients were analyzed by immunohistochemistry for blood vessels (CD31, vascular endothelium), lymphatic vessels (lymphatic vessel endothelial hyaluronan receptor-1 [LYVE-1] and podoplanin) and macrophages (CD68).

resultsCD31+++ blood vessels and CD68+ macrophages were detected in the outer layer of all specimens. LYVE-1 immunoreactivity was registered in single non-endothelial cells in 8 out of 14 (57%) bleb capsule specimens. Podoplanin-immunoreactivity was detected in all cases, located in cells and profiles of the collagen tissue network of the outer and/or the inner capsule layer. However, a colocalization of LYVE-1 and podoplanin as evidence for lymphatic vessels was not detected.

conclusionsWe demonstrate the presence of blood-vessels but absence of lymphatic vessels in non-functioning bleb capsules after GDD-implantation. While the absence of lymphatic vessels might indicate a possible reason for drainage device failure, this needs to be confirmed in upcoming studies, including animal experiments.

Indexed as

Glaucoma Drainage ImplantsAdolescentAdultAgedAntigens, CDAntigens, Differentiation, MyelomonocyticBiomarkersBlood VesselsCD68 MoleculeChildChild, PreschoolFemaleFibrosisGlaucomaHumansLymphatic VesselsAntigens, CDAntigens, Differentiation, MyelomonocyticBiomarkersCD68 antigen, humanCD68 MoleculeLYVE1 protein, humanMembrane GlycoproteinsPDPN protein, humanPECAM1 protein, humanPlatelet Endothelial Cell Adhesion Molecule-1PodoplaninVesicular Transport Proteins

Identifiers

PMID33382078

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.