Evidence map›Paper›PMID 33382032›Full record

Trial reportJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2021

Treatment for patients with sleep apnea on opioids for chronic pain: results of the OpSafe trial.

Sara Wasef, Soodaba Mir, Clodagh Ryan, Rida Waseem, Geoff Bellingham, Alia Kashgari, Jean Wong, Frances Chung

Registry-linked trialOpen access · bronzeAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02513836 (Development of an Innovative Opioid Safety Program in Pain Clinics), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02513836 nacompletednot on this map

Development of an Innovative Opioid Safety Program in Pain Clinics (Op-Safe): A Multi-Centre Project

TypeinterventionalSponsorUniversity Health Network, TorontoRan2015 to 2019Enrolled304ConditionsSleep Disordered BreathingArmsPre-education intervention, Post-education intervention
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Opioids and obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Sara WasefDepartment of Anesthesia and Pain Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Soodaba MirDepartment of Anesthesia and Pain Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Clodagh RyanDepartment of Anesthesia and Pain Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Rida WaseemDepartment of Anesthesia and Pain Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Geoff BellinghamSt Joseph's Chronic Pain Clinic, St Joseph's Hospital, London, Ontario, Canada.
Alia KashgariDepartment of Medicine, Respirology Division, Western University, London, Ontario, Canada.
Jean WongDepartment of Anesthesia and Pain Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Frances ChungDepartment of Anesthesia and Pain Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.
University Health Network · CAUniversity of Toronto · CAIn-Q-Tel · USSt. Joseph's Hospital · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesApproximately 20% of North Americans are afflicted with chronic pain with 3% being opioid users. The objective was to determine whether patients on opioids for chronic pain with newly diagnosed sleep apnea attended sleep clinic review and followed treatment recommendations.

methodsThe study was a post hoc analysis from a multicenter perspective cohort study. Inclusion criteria included adults taking opioid medications for chronic pain for >3 months. Demographic data and daily opioid dose were collected. Sleep apnea was diagnosed via level 1 polysomnography. Patients who attended sleep clinic review were grouped based on the types of treatment they received.

resultsA total of 204 patients completed polysomnography and 58.8% were diagnosed to have sleep apnea (apnea-hypopnea index ≥5 events/h). Of those with sleep apnea, 58% were recommended to have an evaluation by a sleep physician. Body mass index and age were 29.5 ± 6 kg/m² and 56 ± 12 years, respectively. Of those with newly diagnosed sleep apnea, 25% received treatment, with the majority being treated with positive airway pressure therapy, whereas the rest received positional therapy and opioids/sedative reduction. The adherence rate of positive airway pressure therapy was 55% at 1 year. Over 50% of participants on opioids for chronic pain with newly diagnosed sleep apnea declined attendance for sleep clinic review or treatment.

conclusionsThere was a high refusal rate to attend clinic for treatment. Adherence to positive airway pressure therapy was low at 55%. This sheds light on the high rate of treatment nonadherence and the need for further research. CLINICAL

trial registrationRegistry: ClinicalTrials.gov; Name: Opioid Safety Program in Pain Clinics (Op-Safe); URL: https://www.clinicaltrials.gov/ct2/show/NCT02513836; Identifier: NCT02513836.

Indexed as

Chronic PainSleep Apnea, ObstructiveSleep Apnea SyndromesAdultAgedAnalgesics, OpioidCohort StudiesContinuous Positive Airway PressureHumansMiddle AgedAnalgesics, Opioidchronic painopioidsPAP therapypositional therapysleep apnea

Identifiers

PMID33382032
PMCPMC8020677
OpenAlexW3114621463

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.