Evidence map›Paper›PMID 33381925›Full record

ArticlePediatric obesity2021

Genome-wide association study identifying novel variant for fasting insulin and allelic heterogeneity in known glycemic loci in Chilean adolescents: The Santiago Longitudinal Study.

Victoria L Buchanan, Yujie Wang, Estela Blanco, Mariaelisa Graff, Cecilia Albala, Raquel Burrows, José L Santos, Bárbara Angel, Betsy Lozoff, Venkata Saroja Voruganti and 10 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric obesity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 2 countries.

Victoria L BuchananDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0001-9943-9950
Yujie WangDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-1087-2182
Estela BlancoDivision of Academic General Pediatrics, Child Development and Community Health, University of California at San Diego, San Diego, California, USA.ORCID 0000-0002-6232-9210
Mariaelisa GraffDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Cecilia AlbalaDepartment of Public Health Nutrition, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile.ORCID 0000-0002-6135-334X
Raquel BurrowsDepartment of Public Health Nutrition, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile.ORCID 0000-0001-9155-0689
José L SantosDepartment of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID 0000-0003-2895-0369
Bárbara AngelDepartment of Public Health Nutrition, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile.ORCID 0000-0001-8773-5904
Betsy LozoffDepartment of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-0399-582X
Venkata Saroja VorugantiDepartment of Nutrition and UNC Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA.ORCID 0000-0002-8704-4529
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California, USA.ORCID 0000-0002-2756-4370
Yii-Der Ida ChenThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Jie YaoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Jingyi TanThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Carolina DownieDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0001-6972-9981
Heather M HighlandDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-3583-8239
Anne E JusticeDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-8903-8712
Sheila GahaganDivision of Academic General Pediatrics, Child Development and Community Health, University of California at San Diego, San Diego, California, USA.ORCID 0000-0002-1105-7323
Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-8903-0366
University of North Carolina at Chapel Hill · USUCLA Medical Center · USUniversity of Chile · CLUC San Diego Health System · USPontificia Universidad Católica de Chile · CLUniversity of Michigan · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
INSTITUTE FOR TRANSLATIONAL HEALTH SCIENCE (UL1): BPCAUL1RR025014 · NCRR · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2007 to 2011
$51.5M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
ZOLENDRONIC ACID IN CHILDREN W/ SEVERE OSTEOGENESIS IMPERFECTAM01RR000188 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI PLON, SHARON E. · 1985 to 2011
$30.6M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
MULTIDISCIPLINARY CLINICAL AND TRANSLATIONAL SCIENCE (MCTS) PROGRAM (UL1)UL1RR025741 · NCRR · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GREENLAND, PHILIP · 2008 to 2011
$24.7M
Pediatric Trials in Non-Alcoholic Steatohepatitis (NASH)U01DK061734 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROHIT LOOMBA · 2002 to 2026
$24.4M
Continuation of the Non-Alcoholic Steatohepatitis Clinical Research Network (NASHU01DK061730 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI TONASCIA, JAMES A · 2002 to 2018
$23.2M
INDIANA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE (UL1): BPCAUL1RR025761 · NCRR · INDIANA UNIVERSITY INDIANAPOLIS · PI SHEKHAR, ANANTHA · 2008 to 2011
$21.0M
NCATS NIH HHS UL1 TR000040NCI NIH HHS U01 CA164973NCRR NIH HHS M01 RR000188NCRR NIH HHS S10 RR025055NCRR NIH HHS UL1 RR024131NCRR NIH HHS UL1 RR024156NCRR NIH HHS UL1 RR024989NCRR NIH HHS UL1 RR025014NCRR NIH HHS UL1 RR025741NCRR NIH HHS UL1 RR025761NCRR NIH HHS UL1 RR029887NCRR NIH HHS UL1 RR031980NCRR NIH HHS UL1 RR031990NHGRI NIH HHS U01 HG007376NHGRI NIH HHS U01 HG007397NHGRI NIH HHS U01 HG007416NHGRI NIH HHS U01 HG007419NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN268201200008CNHLBI NIH HHS HHSN268201200008INHLBI NIH HHS K99 HL130580NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS R00 HL130580NHLBI NIH HHS R01 HL088530NHLBI NIH HHS R01 HL142302NHLBI NIH HHS R01 HL142825NHLBI NIH HHS R01 HL143885NHLBI NIH HHS T32 HL007055NHLBI NIH HHS T32 HL129982NIA NIH HHS HHSN271201100004CNICHD NIH HHS R01 HD033487NICHD NIH HHS R01 HD057194NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK101855NIDDK NIH HHS R01 DK124097NIDDK NIH HHS U01 DK061713NIDDK NIH HHS U01 DK061718NIDDK NIH HHS U01 DK061728NIDDK NIH HHS U01 DK061730NIDDK NIH HHS U01 DK061731NIDDK NIH HHS U01 DK061732NIDDK NIH HHS U01 DK061734NIDDK NIH HHS U01 DK061737NIDDK NIH HHS U01 DK061738WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

backgroundThe genetic underpinnings of glycemic traits have been understudied in adolescent and Hispanic/Latino (H/L) populations in comparison to adults and populations of European ancestry.

objectiveTo identify genetic factors underlying glycemic traits in an adolescent H/L population.

methodsWe conducted a genome-wide association study (GWAS) of fasting glucose (FG) and fasting insulin (FI) in H/L adolescents from the Santiago Longitudinal Study.

resultsWe identified one novel variant positioned in the CSMD1 gene on chromosome 8 (rs77465890, effect allele frequency = 0.10) that was associated with FI (β = -0.299, SE = 0.054, p = 2.72×10

conclusionOur results exemplify the importance of including populations with diverse ancestral origin and adolescent participants in GWAS of glycemic traits to uncover novel risk loci and expand our understanding of disease aetiology.

Indexed as

Genome-Wide Association StudyInsulinAdolescentBlood GlucoseChileFastingGene FrequencyHumansLongitudinal StudiesMembrane ProteinsPolymorphism, Single NucleotideTumor Suppressor ProteinsBlood GlucoseCSMD1 protein, humanInsulinMembrane ProteinsTumor Suppressor ProteinsadolescentglucoseGWASinsulin

Identifiers

PMID33381925
PMCPMC8711702
OpenAlexW3117189050

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.