Evidence map›Paper›PMID 33381760›Full record

ArticleCerebral cortex communications2020

Subthalamic Nucleus Subregion Stimulation Modulates Inhibitory Control.

Nelleke C van Wouwe, Joseph S Neimat, Wery P M van den Wildenberg, Shelby B Hughes, Alexander M Lopez, Fenna T Phibbs, Jeffrey D Schall, William J Rodriguez, Elise B Bradley, Benoit M Dawant and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral cortex communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Effects of deep brain stimulation target on the activation and suppression of action impulses.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Nelleke C van WouweDepartment of Neurological Surgery, University of Louisville, Louisville, KY 40202 USA.
Joseph S NeimatDepartment of Neurological Surgery, University of Louisville, Louisville, KY 40202 USA.
Wery P M van den WildenbergDepartment of Psychology, University of Amsterdam, Amsterdam 1018 WS, The Netherlands.
Shelby B HughesDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Alexander M LopezDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Fenna T PhibbsDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Jeffrey D SchallDepartment of Psychology, Vanderbilt University, Nashville, TN 37240, USA.
William J RodriguezDepartment of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN 37235, USA.
Elise B BradleyDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Benoit M DawantDepartment of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN 37235, USA.
Scott A WylieDepartment of Neurological Surgery, University of Louisville, Louisville, KY 40202 USA.
Vanderbilt University Medical Center · USVanderbilt University · USNeurological Surgery · USUniversity of Amsterdam · NL

Funding

Computer-Assited Functional NeurosurgeryR01NS095291 · NINDS · VANDERBILT UNIVERSITY · PI DAWANT, BENOIT M., DHAESE, PIERRE F. · 2015 to 2018
$2.4M
Modulating Inhibitory Action Control Systems With Subthalamic Nucleus StimulationR01NS100996 · NINDS · UNIVERSITY OF LOUISVILLE · PI NEIMAT, JOSEPH S, VAN WOUWE, NELLEKE C. · 2018 to 2022
$1.7M
NINDS NIH HHS R01 NS095291NINDS NIH HHS R01 NS100996
6 · The paper itself

Abstract

Patients with Parkinson's disease (PD) often experience reductions in the proficiency to inhibit actions. The motor symptoms of PD can be effectively treated with deep brain stimulation (DBS) of the subthalamic nucleus (STN), a key structure in the frontal-striatal network that may be directly involved in regulating inhibitory control. However, the precise role of the STN in stopping control is unclear. The STN consists of functional subterritories linked to dissociable cortical networks, although the boundaries of the subregions are still under debate. We investigated whether stimulating the dorsal and ventral subregions of the STN would show dissociable effects on ability to stop. We studied 12 PD patients with STN DBS. Patients with two adjacent contacts positioned within the bounds of the dorsal and ventral STN completed two testing sessions (OFF medication) with low amplitude stimulation (0.4 mA) at either the dorsal or ventral contacts bilaterally, while performing the stop task. Ventral, but not dorsal, DBS improved stopping latencies. Go reactions were similar between dorsal and ventral DBS STN. Stimulation in the ventral, but not dorsal, subregion of the STN improved stopping speed, confirming the involvement of the STN in stopping control and supporting the STN functional subregions.

Indexed as

deep brain stimulationinhibitory action controlParkinson’s diseasesubthalamic nucleus

Identifiers

PMID33381760
PMCPMC7750129
OpenAlexW3095327827

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.