Evidence map›Paper›PMID 33381755›Full record

ArticleBrain communications2020

Serum neurofilament light in atrial fibrillation: clinical, neuroimaging and cognitive correlates.

Alexandros A Polymeris, Michael Coslovksy, Stefanie Aeschbacher, Tim Sinnecker, Pascal Benkert, Richard Kobza, Jürg Beer, Nicolas Rodondi, Urs Fischer, Giorgio Moschovitis and 12 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02105844 (Swiss Atrial Fibrillation Cohort Study - SWISS AF), which is not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02105844 active not recruitingnot on this map

Swiss Atrial Fibrillation Cohort Study - SWISS AF

TypeobservationalSponsorUniversity Hospital, Basel, SwitzerlandRan2014 to 2030Enrolled2,415ConditionsAtrial Fibrillation
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Inflammaging and the sex-frailty paradox.Aging clinical and experimental research · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Atrial Fibrillation: Rate Versus Rhythm Control.HCA healthcare journal of medicine · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 6 institutions in 2 countries.

Alexandros A PolymerisDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.ORCID 0000-0002-9475-2208
Michael CoslovksyClinical Trial Unit, Department of Clinical Research, University Hospital Basel and University of Basel, Switzerland.
Stefanie AeschbacherCardiovascular Research Institute Basel (CRIB), Basel, Switzerland.
Tim SinneckerDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Pascal BenkertClinical Trial Unit, Department of Clinical Research, University Hospital Basel and University of Basel, Switzerland.
Richard KobzaDepartment of Cardiology, Cantonal Hospital Lucerne, Lucerne, Switzerland.
Jürg BeerDepartment of Medicine, Cantonal Hospital Baden, Baden, Switzerland.
Nicolas RodondiInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
Urs FischerDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Giorgio MoschovitisCardiology Division, Department of Medicine, EOC Ospedale Regionale di Lugano, Lugano, Switzerland.
Andreas U MonschMemory Clinic, University Department of Geriatric Medicine Felix Platter and University of Basel, Basel, Switzerland.
Anne SpringerCardiovascular Research Institute Basel (CRIB), Basel, Switzerland.
Matthias SchwenkglenksEpidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
Jens WuerfelMedical Image Analysis Center (MIAC) AG and Department of Biomedical Engineering, University of Basel, Basel, Switzerland.
Gian Marco De MarchisDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Philippe A LyrerDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Michael KühneCardiovascular Research Institute Basel (CRIB), Basel, Switzerland.
Stefan OsswaldCardiovascular Research Institute Basel (CRIB), Basel, Switzerland.
David ConenCardiology Division, Department of Medicine, University Hospital Basel, Basel, Switzerland.
Jens KuhleDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Leo H BonatiDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.ORCID 0000-0003-1163-8133
and for the Swiss-AF Investigators
University of Basel · CHUniversity Hospital of Basel · CHUniversity of Bern · CHOspedale regionale di Lugano · CHUniversity Hospital of Zurich · CHUniversity of Lucerne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging evidence suggests that atrial fibrillation is associated with cognitive dysfunction independently of stroke, but the underlying mechanisms remain unclear. In this cross-sectional analysis from the Swiss-atrial fibrillation Study (NCT02105844), we investigated the association of serum neurofilament light protein, a neuronal injury biomarker, with (i) the CHA

Indexed as

atrial fibrillationcognitionneurofilament lightvascular brain lesions

Identifiers

PMID33381755
PMCPMC7753055
OpenAlexW3092052624

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.