Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors at 1 institution in 1 country.
Miguel A OrtegaDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Ramón y Cajal Institute of Sanitary Research (IRYCIS), University Center for the Defense of Madrid (CUD-ACD), Alcalá de Henares, 28047 Madrid, Spain.ORCID https://orcid.org/0000-0003-2588-1708
Oscar Fraile-MartínezDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Ramón y Cajal Institute of Sanitary Research (IRYCIS), University Center for the Defense of Madrid (CUD-ACD), Alcalá de Henares, 28047 Madrid, Spain.ORCID https://orcid.org/0000-0002-4494-6397
Ángel AsúnsoloDepartment of Surgery, Medical and Social Sciences, Faculty of Medicine and Health Sciences, University of Alcala, Ramón y Cajal Institute of Sanitary Research (IRYCIS), Alcala de Henares, Madrid, Spain.ORCID https://orcid.org/0000-0001-7898-4685
Clara Martínez-ViveroDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Ramón y Cajal Institute of Sanitary Research (IRYCIS), University Center for the Defense of Madrid (CUD-ACD), Alcalá de Henares, 28047 Madrid, Spain.ORCID https://orcid.org/0000-0003-0750-1943
Leonel PekarekDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Ramón y Cajal Institute of Sanitary Research (IRYCIS), University Center for the Defense of Madrid (CUD-ACD), Alcalá de Henares, 28047 Madrid, Spain.ORCID https://orcid.org/0000-0002-5966-9003
Santiago CocaDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Ramón y Cajal Institute of Sanitary Research (IRYCIS), University Center for the Defense of Madrid (CUD-ACD), Alcalá de Henares, 28047 Madrid, Spain.ORCID https://orcid.org/0000-0002-4705-8651
Luis G GuijarroDepartment of System Biology, Unit of Biochemistry and Molecular Biology (CIBEREHD), University of Alcala, Alcalá de Henares, Spain.ORCID https://orcid.org/0000-0003-4979-2136
Melchor Álvarez-MonDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Ramón y Cajal Institute of Sanitary Research (IRYCIS), University Center for the Defense of Madrid (CUD-ACD), Alcalá de Henares, 28047 Madrid, Spain.ORCID https://orcid.org/0000-0003-1309-7510
Julia BujánDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Ramón y Cajal Institute of Sanitary Research (IRYCIS), University Center for the Defense of Madrid (CUD-ACD), Alcalá de Henares, 28047 Madrid, Spain.ORCID https://orcid.org/0000-0003-2419-2476
Natalio García-HonduvillaDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Ramón y Cajal Institute of Sanitary Research (IRYCIS), University Center for the Defense of Madrid (CUD-ACD), Alcalá de Henares, 28047 Madrid, Spain.ORCID https://orcid.org/0000-0003-0904-6198
Felipe SainzDepartment of Surgery, Medical and Social Sciences, Faculty of Medicine and Health Sciences, University of Alcala, Ramón y Cajal Institute of Sanitary Research (IRYCIS), Alcala de Henares, Madrid, Spain.ORCID https://orcid.org/0000-0003-1243-9697
Universidad de Alcalá · ES
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
Chronic venous disease (CVeD) has a remarkable prevalence, with an estimated annual incidence of 2%. It has been demonstrated how the loss of homeostatic mechanisms in the vein wall can take part in the physiopathology of CVeD. In this regard, it has been described how different axis, such as IGF-1/PAPP-A/STC-2 axis, may play an essential role in tissue homeostasis. The aim of this research is to study both genetic and protein expressions of the IGF-1/PAPP-A/STC-2 axis in CVeD patients. It is a cross-sectional study in which genetic (RT-qPCR) and protein (immunohistochemistry) expression analysis techniques were accomplished in saphenous veins from CVeD patients (
Indexed as
Gene Expression RegulationAdultAgedAged, 80 and overBody Mass IndexCross-Sectional StudiesEndothelium, VascularFemaleGene Expression ProfilingGenetic MarkersGlycoproteinsHomeostasisHumansInsulin-Like Growth Factor IIntercellular Signaling Peptides and ProteinsMaleGenetic MarkersGlycoproteinsIGF1 protein, humanInsulin-Like Growth Factor IIntercellular Signaling Peptides and ProteinsPAPPA protein, humanPregnancy-Associated Plasma Protein-ASTC2 protein, human
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Chronic Venous Disease Patients Showed Altered Expression of IGF-1/PAPP-A/STC-2 Axis in the Vein Wall. · full record | OpenQuestion