Evidence map›Paper›PMID 33381520›Full record

ArticleFrontiers in molecular biosciences2020

Lack of a Clear Behavioral Phenotype in an Inducible FXTAS Mouse Model Despite the Presence of Neuronal FMRpolyG-Positive Aggregates.

Saif N Haify, Ruchira S D Mankoe, Valerie Boumeester, Esmay C van der Toorn, Rob F M Verhagen, Rob Willemsen, Renate K Hukema, Laurens W J Bosman

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Glial dysregulation in the human brain in fragile X-associated tremor/ataxia syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  4. Mouse models of fragile X-related disorders.Disease models & mechanisms · 2023
    Review
  5. Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Saif N HaifyDepartment of Clinical Genetics, Erasmus MC, Rotterdam, Netherlands.
Ruchira S D MankoeDepartment of Clinical Genetics, Erasmus MC, Rotterdam, Netherlands.
Valerie BoumeesterDepartment of Clinical Genetics, Erasmus MC, Rotterdam, Netherlands.
Esmay C van der ToornDepartment of Clinical Genetics, Erasmus MC, Rotterdam, Netherlands.
Rob F M VerhagenDepartment of Clinical Genetics, Erasmus MC, Rotterdam, Netherlands.
Rob WillemsenDepartment of Clinical Genetics, Erasmus MC, Rotterdam, Netherlands.
Renate K HukemaDepartment of Clinical Genetics, Erasmus MC, Rotterdam, Netherlands.
Laurens W J BosmanDepartment of Neuroscience, Erasmus MC, Rotterdam, Netherlands.
Erasmus MC · NLErasmus University Rotterdam · NLRotterdam University of Applied Sciences · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a rare neurodegenerative disorder caused by a 55-200 CGG repeat expansion in the 5' untranslated region of the Fragile X Mental Retardation 1 (

Indexed as

FMR1FXTASmouse behaviornuclear inclusionsrepeat expansion

Identifiers

PMID33381520
PMCPMC7768028
OpenAlexW3111493926

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.