ReviewFrontiers in cell and developmental biology2020
More Than Mortar: Glia as Architects of Nervous System Development and Disease.
Review in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed.
- Light- and temperature-sensitive seizures are regulated by spatially distinct cortex glial populations in the central nervous system.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Glia generate distinct visual processing centres by locally inhibiting ERK activity in an optic lobe neuroepithelium.bioRxiv : the preprint server for biology · 2026Article
- Neuronal Calcium Signaling and Cytoskeletal Dynamics in Neurodegeneration.International journal of molecular sciences · 2026Review
- Glia Regulate the Timing of Photoreceptor Differentiation in the Drosophila Visual System.Glia · 2026Article
- Review
- Developmentally-regulated post-apocrine cell death ofFrontiers in cell and developmental biology · 2026Article
- The mechanistic role of non-coding RNAs in febrile seizures in children: their potential as biomarkers and therapeutic targets-a systematic review.Translational pediatrics · 2025Review
- Steroid hormone-dependent glial-neuronal interaction promotes brain development duringbioRxiv : the preprint server for biology · 2025Article
- Sustained breastfeeding associations with brain structure and cognition from late childhood to early adolescence.Pediatric research · 2025Article
- The role of endothelial-derived factors in neural tube development: implications for organoid models.Open biology · 2025Review
- Molecular profiling of invertebrate glia.Glia · 2025Review
- Impact of neuroinflammation on brain glutamate and dopamine signalling in schizophrenia: an update.Metabolic brain disease · 2025Review
- Stereo-seq of the prefrontal cortex in aging and Alzheimer's disease.Nature communications · 2025Article
- Innovating beyond electrophysiology through multimodal neural interfaces.Nature reviews electrical engineering · 2025Article
- Dialogue mechanisms between astrocytic and neuronal networks: A whole-brain modelling approach.PLoS computational biology · 2025Article
- Astrocyte alterations in α-synucleinopathies.Frontiers in cellular neuroscience · 2025Review
- Coordinated neuron-glia regeneration through Notch signaling in planarians.PLoS genetics · 2025Article
- Glial Regulation of Circuit Wiring, Firing, and Expiring in theCold Spring Harbor perspectives in biology · 2024Review
- Neurodevelopmental Abnormalities in Down Syndrome: Assessing Structural and Functional Deficits.Cureus · 2024Review
- Nasal obstruction during development leads to defective synapse elimination, hypersynchrony, and impaired cerebellar function.Communications biology · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Glial cells are an essential component of the nervous system of vertebrates and invertebrates. In the human brain, glia are as numerous as neurons, yet the importance of glia to nearly every aspect of nervous system development has only been expounded over the last several decades. Glia are now known to regulate neural specification, synaptogenesis, synapse function, and even broad circuit function. Given their ubiquity, it is not surprising that the contribution of glia to neuronal disease pathogenesis is a growing area of research. In this review, we will summarize the accumulated evidence of glial participation in several distinct phases of nervous system development and organization-neural specification, circuit wiring, and circuit function. Finally, we will highlight how these early developmental roles of glia contribute to nervous system dysfunction in neurodevelopmental and neurodegenerative disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.